| Complement factor H variant Y402H is not a risk factor for preeclampsia in the Finnish population. | |
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MedLine Citation:
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PMID: 19003634 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Variations in complement factor H, which down-regulates the activity of the alternative complement pathway, have been associated with different vascular disorders. Here we examine whether factor H variation is involved in the etiology of preeclampsia. METHODS: We studied 110 women with preeclampsia and 99 controls for complement factor H variations by sequencing. RESULTS: No significant differences in the genotype or allele frequencies of the Y402H variant were detected between the two groups. No sequence variations were detected in the short consensus repeat domain 20 of the gene. CONCLUSIONS: Neither the Y402H variant, nor mutations in the short consensus repeat domain 20 of the gene is associated with preeclampsia. For examination of possible links to other polymorphisms or detection of small genotypic effects, studies in larger sample sets are warranted. |
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Authors:
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M Kaare; S Seitsonen; I Jarvela; S Meri; H Laivuori |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy Volume: 27 ISSN: 1525-6065 ISO Abbreviation: Hypertens Pregnancy Publication Date: 2008 |
Date Detail:
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Created Date: 2008-11-12 Completed Date: 2009-02-17 Revised Date: 2009-05-12 |
Medline Journal Info:
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Nlm Unique ID: 9421297 Medline TA: Hypertens Pregnancy Country: United States |
Other Details:
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Languages: eng Pagination: 328-36 Citation Subset: IM |
Affiliation:
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Folkhälsan Institute of Genetics, University of Helsinki, Finland. milja.kaare@helsinki.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alleles Complement Factor H / genetics European Continental Ancestry Group Female Finland Gene Frequency Genotype Humans Pre-Eclampsia / genetics* Pregnancy Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/complement factor H, human; 80295-65-4/Complement Factor H |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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