| Complement and dysbiosis in periodontal disease. | |
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MedLine Citation:
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PMID: 22964237 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Signaling crosstalk between complement and Toll-like receptors (TLRs) normally serves to coordinate host immunity. However, the periodontal bacterium Porphyromonas gingivalis expresses C5 convertase-like enzymatic activity and adeptly exploits complement-TLR crosstalk to subvert host defenses and escape elimination. Intriguingly, this defective immune surveillance leads to the remodeling of the periodontal microbiota to a dysbiotic state that causes inflammatory periodontitis. Understanding the mechanisms by which P. gingivalis modulates complement function to cause dysbiosis offers new targets for complement therapeutics. |
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Authors:
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George Hajishengallis; John D Lambris |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Immunobiology Volume: 217 ISSN: 1878-3279 ISO Abbreviation: Immunobiology Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-09-11 Completed Date: 2013-03-14 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8002742 Medline TA: Immunobiology Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1111-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier GmbH. All rights reserved. |
Affiliation:
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University of Pennsylvania School of Dental Medicine, Department of Microbiology, Philadelphia, PA 19104, USA. geoh@upenn.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacteroidaceae Infections
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immunology,
metabolism,
microbiology Complement Activation* Complement C3-C5 Convertases / metabolism* Complement System Proteins / immunology* Humans Microbial Interactions Periodontitis / immunology*, metabolism, microbiology* Porphyromonas gingivalis / enzymology, metabolism, pathogenicity* Signal Transduction Toll-Like Receptors / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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AI030040/AI/NIAID NIH HHS; AI068730/AI/NIAID NIH HHS; AI072106/AI/NIAID NIH HHS; DE015254/DE/NIDCR NIH HHS; DE018292/DE/NIDCR NIH HHS; DE021580/DE/NIDCR NIH HHS; DE021685/DE/NIDCR NIH HHS; GM062134/GM/NIGMS NIH HHS; P01 AI068730/AI/NIAID NIH HHS; R01 AI030040/AI/NIAID NIH HHS; R01 AI072106/AI/NIAID NIH HHS; R01 DE015254/DE/NIDCR NIH HHS; R01 DE018292/DE/NIDCR NIH HHS; R01 DE021685/DE/NIDCR NIH HHS; R01 GM062134/GM/NIGMS NIH HHS; RC4 DE021580/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Toll-Like Receptors; 9007-36-7/Complement System Proteins; EC 3.4.21.-/Complement C3-C5 Convertases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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