Document Detail


Complement and dysbiosis in periodontal disease.
MedLine Citation:
PMID:  22964237     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Signaling crosstalk between complement and Toll-like receptors (TLRs) normally serves to coordinate host immunity. However, the periodontal bacterium Porphyromonas gingivalis expresses C5 convertase-like enzymatic activity and adeptly exploits complement-TLR crosstalk to subvert host defenses and escape elimination. Intriguingly, this defective immune surveillance leads to the remodeling of the periodontal microbiota to a dysbiotic state that causes inflammatory periodontitis. Understanding the mechanisms by which P. gingivalis modulates complement function to cause dysbiosis offers new targets for complement therapeutics.
Authors:
George Hajishengallis; John D Lambris
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Immunobiology     Volume:  217     ISSN:  1878-3279     ISO Abbreviation:  Immunobiology     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-09-11     Completed Date:  2013-03-14     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  8002742     Medline TA:  Immunobiology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1111-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier GmbH. All rights reserved.
Affiliation:
University of Pennsylvania School of Dental Medicine, Department of Microbiology, Philadelphia, PA 19104, USA. geoh@upenn.edu
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MeSH Terms
Descriptor/Qualifier:
Bacteroidaceae Infections / immunology,  metabolism,  microbiology
Complement Activation*
Complement C3-C5 Convertases / metabolism*
Complement System Proteins / immunology*
Humans
Microbial Interactions
Periodontitis / immunology*,  metabolism,  microbiology*
Porphyromonas gingivalis / enzymology,  metabolism,  pathogenicity*
Signal Transduction
Toll-Like Receptors / metabolism*
Grant Support
ID/Acronym/Agency:
AI030040/AI/NIAID NIH HHS; AI068730/AI/NIAID NIH HHS; AI072106/AI/NIAID NIH HHS; DE015254/DE/NIDCR NIH HHS; DE018292/DE/NIDCR NIH HHS; DE021580/DE/NIDCR NIH HHS; DE021685/DE/NIDCR NIH HHS; GM062134/GM/NIGMS NIH HHS; P01 AI068730/AI/NIAID NIH HHS; R01 AI030040/AI/NIAID NIH HHS; R01 AI072106/AI/NIAID NIH HHS; R01 DE015254/DE/NIDCR NIH HHS; R01 DE018292/DE/NIDCR NIH HHS; R01 DE021685/DE/NIDCR NIH HHS; R01 GM062134/GM/NIGMS NIH HHS; RC4 DE021580/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Toll-Like Receptors; 9007-36-7/Complement System Proteins; EC 3.4.21.-/Complement C3-C5 Convertases
Comments/Corrections

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