Document Detail


Complement-dependent pathogenicity of brain-specific antibodies in cerebrospinal fluid.
MedLine Citation:
PMID:  23031833     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The specificity and potential pathogenicity of autoantibodies vary between neurological diseases. It is often unclear whether their detection in cerebrospinal fluid (CSF) is a consequence or a cause of pathology. The goal was to test whether administration of brain-specific antibodies into CSF would be sufficient for pathology. Purified immunoglobulin G from a neuromyelitis optica patient was injected intrathecally with complement to naïve mice. Histopathological analysis at 7days revealed damage to the ependyma, disruption of the CSF parenchymal barrier and pathologic lesions, distant from the site of injection. In the absence of complement there was no pathology. Autoantibody and complement in CSF are thus sufficient to initiate a pathologic cascade.
Authors:
Nasrin Asgari; Reza Khorooshi; Søren T Lillevang; Trevor Owens
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-29
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  -     ISSN:  1872-8421     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
Neurobiology, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsloewsvej 25, DK-5000 Odense C, Denmark; Institute of Regional Health Services Research, University of Southern Denmark, J.B. Winsloewsvej 19, DK-5000 Odense C, Denmark.
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