Document Detail

Complement-dependent and -independent pathways of T cell-B cell cooperation.
MedLine Citation:
PMID:  323359     Owner:  NLM     Status:  MEDLINE    
BDF1 mice treated with CoV had markedly reduced levels (less than 20%) of native serum C3 32 hr later, whereas the frequency of splenic CR+ cells was normal. CoV treatment before immunization reduced the IgM PFC response to a T-dependent antigen (TNP-SRBC) by more than 60%. Inclusion of highly specific anti-C3 antibody had no effect on the T-dependent IgM response of CR- B cells. The residual PFC responses in cultures of unfractionated spleen cells treated with anti-C3 could be largely or completely accounted for by CR- B cells in the cultures. The effect of anti-C3 antibody was not due to cytotoxicity. These data collectively indicate that the effect of CoV on T-dependent antibody responses is due to decreased C3 in serum rather than to interaction of C receptors directly with CoV or with C3 cleavage products. They suggest the existence of at least two distinct pathways of T-B cooperation, one in which C3 is an obligatory participant and another in which it may be uninvolved.
G K Lewis; R Ranken; J W Goodman
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  118     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-06-30     Completed Date:  1977-06-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1744-7     Citation Subset:  AIM; IM    
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MeSH Terms
Antibody Formation
Antibody Specificity
B-Lymphocytes / immunology*
Complement C3 / analysis,  antagonists & inhibitors
Complement System Proteins*
Cytotoxicity Tests, Immunologic
Erythrocytes / immunology
Hemolytic Plaque Technique
Immunoglobulin M
Mice, Inbred Strains
Snake Venoms / pharmacology
T-Lymphocytes / immunology*
Trinitrobenzenes / immunology
Reg. No./Substance:
0/Antibodies; 0/Antigens; 0/Complement C3; 0/Immunoglobulin M; 0/Snake Venoms; 0/Trinitrobenzenes; 9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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