Document Detail


Complement and contact activation during cardiovascular operations in infants.
MedLine Citation:
PMID:  9485258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: By comparing the results of cardiac operations with or without cardiopulmonary bypass (CPB) in infants in a prospective study, we sought to determine which part of the postoperative systemic inflammatory response was caused by CPB. METHODS: Thirty-five patients were divided into two groups: 11 infants operated on without CPB and 24 infants operated on with CPB. Blood samples were drawn before, during, and after the operation. We assessed complement function and the concentrations or activities of C1q, C3, C4, C1 inhibitor, factor B, the activated split product C3a, and prekallikrein and factor XIIa of the contact system. RESULTS: All of the patients exhibited a decrease of complement proteins. This was greater in infants who underwent CPB. A increase in C3a and factor XIIa and changes in prekallikrein activity occurred only in infants during CPB. CONCLUSIONS: Complement activation occurs in all infants, but is significantly higher in the group with CPB. Contact activation only occurs in patients who undergo CPB. Thus, the inflammatory response is caused by the use of a CPB circuit and to a lesser degree by surgical procedures and anesthesia.
Authors:
J Sonntag; I Dähnert; B Stiller; R Hetzer; P E Lange
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  65     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-03-13     Completed Date:  1998-03-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  525-31     Citation Subset:  AIM; IM    
Affiliation:
Department of Neonatology, Virchow-Charité-Hospital, Humboldt University, Berlin, Germany.
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MeSH Terms
Descriptor/Qualifier:
Cardiac Surgical Procedures*
Cardiopulmonary Bypass / adverse effects
Complement Activation*
Complement Factor B / analysis
Complement System Proteins / analysis
Factor XIIa / analysis
Female
Heart Defects, Congenital / surgery
Humans
Infant
Infant, Newborn
Male
Prekallikrein / metabolism
Prospective Studies
Systemic Inflammatory Response Syndrome / etiology,  metabolism
Chemical
Reg. No./Substance:
9007-36-7/Complement System Proteins; 9055-02-1/Prekallikrein; EC 3.4.21.38/Factor XIIa; EC 3.4.21.47/Complement Factor B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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