| Complement activation and interleukin response in major abdominal surgery. | |
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MedLine Citation:
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PMID: 22229650 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Study Objective: The objective of this study was to evaluate whether major abdominal surgery leads to complement activation and interleukin response and whether the kind of anaesthesia influence complement activation and the release of inflammatory interleukins. Design: Prospective and randomised trial. Setting: Operating room and in the postoperative recovery area. Patients: Fifty patients undergoing open major colo-rectal surgery due to cancer disease or inflammatory bowel disease were studied. Interventions: Twenty-five patients were given total intravenous anaesthesia (TIVA) with propofol and remifentanil and 25 were given inhalational anaesthesia with sevoflurane and fentanyl. Measurements: In order to determine complement activation (C3a and SC5b-9) and the release of pro- and anti-inflammatory interleukins (tumour necrosis factor-α (TNF-α)), interleukin-1β (IL-1β), IL-6, IL-8, IL-4 and IL-10) blood samples were drawn pre-operatively, 60 minutes after start of surgery, 30 minutes after end of surgery and 24 hours postoperatively. Main Results: Complement was activated and pro-inflammatory interleukins (IL-6 and IL-8) and anti-inflammatory interleukins (IL-10) were released during major colorectal surgery. There was no significant difference between TIVA and inhalational anaesthesia regarding complement activation and cytokine release. Conclusion: Major colorectal surgery leads to activation of the complement cascade and the release of both pro-inflammatory and anti-inflammatory cytokines. There are no significant differences between total intravenous anaesthesia (TIVA) with propofol and remifentanil and inhalational anaesthesia with sevoflurane and fentanyl regarding complement activation and the release of pro- and anti-inflammatory interleukins. |
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Authors:
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Andreas L Kvarnström; Roman T Sarbinowski; Jan-Peter Bengtson; Lena M Jacobsson; Anders L Bengtsson |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-10 |
Journal Detail:
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Title: Scandinavian journal of immunology Volume: - ISSN: 1365-3083 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0323767 Medline TA: Scand J Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Scandinavian Journal of Immunology © 2012 Blackwell Publishing Ltd. |
Affiliation:
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Department of Anaesthesiology & Intensive Care, Sahlgrenska University Hospital/East, Gothenburg, Sweden Department of Anaesthesiology, St Bernards Hospital, Gibraltar, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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