Document Detail

Complement activation in patients with sepsis is in part mediated by C-reactive protein.
MedLine Citation:
PMID:  9419173     Owner:  NLM     Status:  MEDLINE    
The involvement of C-reactive protein (CRP) in the activation of complement in patients with sepsis was investigated. In 104 patients with infections of varying severity, circulating levels of CRP-complement complexes, which are specific indicators for CRP-mediated complement activation, were assessed. Complement-CRP complexes were increased in almost all patients and correlated significantly with levels of C3a (r = .59; P < .001) and C-reactive protein (r = .76; P < .001). In addition, they correlated with levels of secretory phospholipase A2 (r = .59; P < .001). Levels of complement-CRP complexes in patients with a pneumococcal type of infection were similar to those in patients with other types of infections. Complement-CRP complexes were significantly higher in patients with shock (P = .01) and in patients who died (P = .03). These results demonstrate that part of the complement activation in patients with sepsis is independent from a direct interaction with microorganisms but rather results from an endogenous mechanism involving CRP.
G J Wolbink; A W Bossink; A B Groeneveld; M C de Groot; L G Thijs; C E Hack
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  177     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-01-23     Completed Date:  1998-01-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  81-7     Citation Subset:  AIM; IM    
Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, Academic Medical Centre, University of Amsterdam.
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MeSH Terms
C-Reactive Protein / analysis,  immunology*,  metabolism
Complement Activation*
Complement C3a / analysis,  immunology
Complement System Proteins / immunology,  metabolism
Phospholipases A / analysis,  metabolism
Phospholipases A2
Pneumococcal Infections / immunology
Sepsis / blood,  immunology*,  mortality
Shock, Septic / immunology
Reg. No./Substance:
80295-42-7/Complement C3a; 9007-36-7/Complement System Proteins; 9007-41-4/C-Reactive Protein; EC 3.1.1.-/Phospholipases A; EC A2

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