Document Detail


Complement activation in patients with primary antiphospholipid syndrome.
MedLine Citation:
PMID:  18625630     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the significance of complement activation in patients with primary antiphospholipid syndrome (APS). METHODS: Thirty-six patients with primary APS, 42 control patients with non-systemic lupus erythematosus (SLE) connective tissue diseases, and 36 healthy volunteers were analysed retrospectively. Serum complement levels (C3, C4, CH(50)) and anaphylatoxins (C3a, C4a, C5a) were examined in all subjects, and serum complement regulatory factors (factor H and factor I) were measured in patients with primary APS. Plasma anticoagulant activity was determined in a mixing test using the activated partial thromboplastin time. RESULTS: Serum complement levels were significantly lower in patients with primary APS than in patients with non-SLE connective tissue diseases (mean (SD) C3: 81.07 (17.86) vs 109.80 (22.76) mg/dl, p<0.001; C4: 13.04 (8.49) vs 21.70 (6.96) mg/dl, p<0.001; CH(50): 31.32 (8.76) vs 41.40 (7.70) U/ml, p<0.001) or healthy volunteers. Only two healthy subjects with low serum C4 levels showed hypocomplementaemia, whereas most patients with primary APS showed raised serum C3a and C4a. No subjects showed raised C5a. Patients with primary APS with low serum C3 or C4 had significantly higher levels of C3a or C4a than healthy controls. No patients had low serum complement regulatory factors. Among patients with primary APS, hypocomplementaemia was significantly more common in those with high anticoagulant activity than in those with low or normal activity. CONCLUSION: Hypocomplementaemia is common in patients with primary APS, reflecting complement activation and consumption, and was correlated with anticoagulant activity, suggesting that antiphospholipid antibodies may activate monocytes and macrophages via anaphylatoxins produced in complement activation.
Authors:
K Oku; T Atsumi; M Bohgaki; O Amengual; H Kataoka; T Horita; S Yasuda; T Koike
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-14
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  68     ISSN:  1468-2060     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-13     Completed Date:  2009-06-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  1030-5     Citation Subset:  IM    
Affiliation:
Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Antigen-Antibody Complex / analysis
Antiphospholipid Syndrome / blood,  immunology*
Blood Coagulation
Case-Control Studies
Complement Activation / immunology*
Complement C3 / analysis
Complement C3a / analysis
Complement C4 / analysis
Complement C4a / analysis
Connective Tissue Diseases / immunology
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Retrospective Studies
Statistics, Nonparametric
Tumor Necrosis Factor-alpha / blood
Young Adult
Chemical
Reg. No./Substance:
0/Antigen-Antibody Complex; 0/Complement C3; 0/Complement C4; 0/Tumor Necrosis Factor-alpha; 80295-42-7/Complement C3a; 80295-49-4/Complement C4a

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