Document Detail

Complement activation in fetuses: assessment by the levels of complement components and split products in cord blood.
MedLine Citation:
PMID:  3497734     Owner:  NLM     Status:  MEDLINE    
The whole complement activity (CH50) and concentrations of components (C1q, C3, and C4) and C3 split product (C3d) were determined in the cord blood of 172 newborns between 16 and 42 weeks of gestation. Histological examination of their placentas revealed that the extent of complement activation was significantly higher in those with some degree of inflammation in the amnion than in those with normal amnion. The correlation between the complement levels and gestational age was higher in those with no amnionitis. In some cases the level of C3d at an early gestational age was as high as that in adults. The C3 activation system seems to be well developed even before week 25 of gestation. Among the complement components, C3d was the most sensitive indicator of placenta inflammation. As placenta inflammation may reflect intrauterine infection, the measurement of C3d levels may be of diagnostic value.
A Miyano; M Nakayama; T Fujita; H Kitajima; S Imai; A Shimizu
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Diagnostic and clinical immunology     Volume:  5     ISSN:  0895-0458     ISO Abbreviation:  Diagn Clin Immunol     Publication Date:  1987  
Date Detail:
Created Date:  1987-10-21     Completed Date:  1987-10-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8705862     Medline TA:  Diagn Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  86-90     Citation Subset:  IM    
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MeSH Terms
Complement Activating Enzymes / analysis
Complement Activation*
Complement C1 / analysis
Complement C1q
Complement C3 / analysis
Complement C3d
Complement C4 / analysis
Complement System Proteins / analysis*
Fetal Blood / analysis*
Fetus / immunology*
Gestational Age
Infant, Newborn
Placenta / pathology
Reg. No./Substance:
0/Complement C1; 0/Complement C3; 0/Complement C4; 80295-33-6/Complement C1q; 80295-45-0/Complement C3d; 9007-36-7/Complement System Proteins; EC 3.-/Complement Activating Enzymes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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