Document Detail

Complement activation and group B streptococcal infection in the newborn: similarities to endotoxin shock.
MedLine Citation:
PMID:  341069     Owner:  NLM     Status:  MEDLINE    
Serial measurements of CH50, C3, C4, and factor B were performed on three newborn infants with group B streptococcal sepsis. Two of the septic infants had a colonized but noninfected identical twin. All three infants with group B streptococcal sepsis had hypotension, prolonged coagulation times, neutropenia, and respiratory failure. During the course of the sepsis, factor B was depressed 30% to 35%, C3 was depressed 40% to 60%, and CH50 was depressed by 100% when compared to their cord blood levels. Two of the infants also had a 50% to 70% depression of C4. In contrast, no significant decrease in complement levels occurred in the siblings of the twins or in two additional control infants. These data are characteristic of older patients with Gram-negative sepsis and strongly suggest that the group B Streptococcus has endotoxin-like properties.
L J Fenton; R C Strunk
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatrics     Volume:  60     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1977 Dec 
Date Detail:
Created Date:  1978-03-21     Completed Date:  1978-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  901-7     Citation Subset:  AIM; IM    
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MeSH Terms
Complement C3 / analysis*
Complement C4 / analysis*
Complement Inactivator Proteins
Fetal Blood / immunology
Infant, Newborn
Infant, Newborn, Diseases / immunology*
Shock, Septic / immunology*
Streptococcal Infections / immunology*
Streptococcus agalactiae / immunology
Reg. No./Substance:
0/Complement C3; 0/Complement C4; 0/Complement Inactivator Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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