Document Detail


Complement activation during low-density lipoprotein apheresis.
MedLine Citation:
PMID:  1482327     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Complement system activation was investigated in two girls with familial homozygous hypercholesterolemia undergoing two monthly sessions on LA15 or LA40 (Kaneka liposorber). We determined blood levels of C3c and C3a, leukocyte counts, and plasma levels of C3c and C3a in the extracorporeal circulation device at the start of the sessions and 15 and either 60 or 120 min into them. Sequential eluates were collected from LA40 at the end of the sessions (0.5M NaCl, 1M hydroxylamine). Anaphylatoxin C3a increased throughout, especially with LA40. As previously reported, C3a was trapped in the dextran column but was noticeably present in efferent plasma. Besides many proteins, nonnative complement fragments bearing C3a and C3d antigens were detected in almost all the eluates, suggesting possible in situ complement activation. Practically, complement activation induced by the first filter is a risk; long-term side effects may arise from this extracorporeal circulation device.
Authors:
A Tridon; J B Palcoux; P Jouanel; M J Bezou; M Coulet; G Betail
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Artificial organs     Volume:  16     ISSN:  0160-564X     ISO Abbreviation:  Artif Organs     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-02-08     Completed Date:  1993-02-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  577-85     Citation Subset:  IM    
Affiliation:
Laboratoire d'Immunologie, CHRU Clermont-Ferrand, France.
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MeSH Terms
Descriptor/Qualifier:
Blood Component Removal* / adverse effects,  instrumentation
Child
Complement Activation*
Complement C3 / analysis
Female
Humans
Hyperlipoproteinemia Type II / blood,  immunology,  therapy*
Leukocyte Count
Lipoproteins, LDL*
Chemical
Reg. No./Substance:
0/Complement C3; 0/Lipoproteins, LDL

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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