Document Detail


Complement activation by house dust: reduced reactivity of serum complement in patients with bronchial asthma.
MedLine Citation:
PMID:  1809688     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Among ten different allergens, house-dust extract proved to be the most potent complement activator. It was therefore chosen to investigate the susceptibility of complement in the serum and bronchoalveolar lavage fluid of patients with extrinsic asthma and control persons. Complement activation in serum was assessed by the appearance of C3d as well as the activation-specific protein-protein complexes C1rs-C1inhibitor (classical pathway) and C3b(Bb)P (alternative pathway). Complement was activated via both the classical and the alternative pathway in a dose- and time-dependent manner. In contrast to earlier observations, however, complement was less affected in the serum of asthmatics than in the serum of normal individuals. Differences were restricted to alternative-pathway activation, probably due to preactivation and/or a significantly higher serum concentration of the regulatory protein factor H in asthmatic patients. In vitro generation of C3a in bronchoalveolar lavage fluid could not be achieved, although the presence of alternative pathway proteins C3, B and D was demonstrated.
Authors:
F F Castro; M Schmitz-Schumann; U Rother; M Kirschfink
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International archives of allergy and applied immunology     Volume:  96     ISSN:  0020-5915     ISO Abbreviation:  Int. Arch. Allergy Appl. Immunol.     Publication Date:  1991  
Date Detail:
Created Date:  1992-05-28     Completed Date:  1992-05-28     Revised Date:  2006-04-19    
Medline Journal Info:
Nlm Unique ID:  0404561     Medline TA:  Int Arch Allergy Appl Immunol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  305-10     Citation Subset:  IM    
Affiliation:
Institute of Immunology, University of Heidelberg, FRG.
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MeSH Terms
Descriptor/Qualifier:
Allergens / administration & dosage
Anaphylatoxins / metabolism
Asthma / blood,  immunology*,  physiopathology
Bronchial Provocation Tests
Bronchoalveolar Lavage Fluid / immunology
Complement Activation / physiology*
Complement C3a / analysis
Dust / analysis*
Enzyme-Linked Immunosorbent Assay
Humans
Kinetics
Chemical
Reg. No./Substance:
0/Allergens; 0/Anaphylatoxins; 0/Dust; 80295-42-7/Complement C3a

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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