| Complement activation and anaphylatoxin (C3a and C5a) formation in preeclampsia and by amniotic fluid. | |
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MedLine Citation:
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PMID: 2784554 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to determine whether the biologically active complement peptides C3a and C5a are formed in pregnancy and whether amniotic fluid can activate complement. C3a and C5a are formed when complement is activated. They increase smooth-muscle contraction, vascular permeability, and histamine release from mast cells and basophils. Thirty pregnant women were studied, 16 with uncomplicated and 14 with preeclamptic pregnancies. The plasma C3a and C5a concentrations before delivery were significantly higher in the preeclamptic than in the normal group. The concentrations returned to normal within 1 week. Plasma, serum, and amniotic fluid from 12 pregnant women (eight uncomplicated and four preeclamptic pregnancies) were drawn in connection with delivery. Amniotic fluid was incubated in fresh autologous serum at 37C for 15 minutes. A dose-dependent formation of C3a and C5a was registered with increasing amounts of amniotic fluid. |
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Authors:
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M Haeger; A Bengtson; K Karlsson; M Heideman |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 73 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 1989 Apr |
Date Detail:
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Created Date: 1989-04-27 Completed Date: 1989-04-27 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 551-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Gynecology and Obstetrics, Sahlgren Hospital, Gothenburg, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amniotic Fluid / immunology* Anaphylatoxins / biosynthesis* Complement Activation* Complement C3 / analogs & derivatives, analysis, biosynthesis* Complement C3a Complement C5 / analogs & derivatives, analysis, biosynthesis* Complement C5a Complement C5a, des-Arginine Female Humans Peptide Biosynthesis* Pre-Eclampsia / immunology* Pregnancy / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Anaphylatoxins; 0/Complement C3; 0/Complement C5; 0/Complement C5a, des-Arginine; 0/complement C3a, des-Arg-(77); 80295-42-7/Complement C3a; 80295-54-1/Complement C5a |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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