| Complement activation after lumbosacral ventral root avulsion injury. | |
| | |
MedLine Citation:
|
PMID: 16289555 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A lumbosacral ventral root avulsion (VRA) injury results in a pronounced loss of motoneurons, in part due to apoptosis. Caspase inhibitors may rescue motoneurons after a VRA in neonatal rats, but this treatment approach has been unsuccessful to protect motoneurons subjected to the same injury in adult rats. Other mechanisms may contribute to the retrograde motoneuron death encountered in adult animals. Here, we study whether the complement system, a part of the innate immune system, contributes to motoneuron death after a lumbosacral VRA. Adult Sprague-Dawley rats underwent a unilateral L5-S2 VRA injury. At 10 days postoperatively, quantitative immunohistochemical studies demonstrated that the lytic membrane attack complex (MAC) targeted approximately 38% of axotomized motoneurons. The MAC inhibitor Clusterin was concurrently expressed at significantly higher levels in astrocytes and de novo in 30% of the remaining motoneurons. Our data suggest that complement activation and necrosis contribute to motoneuron death after lumbosacral VRA injuries. We speculate that inhibition of MAC may constitute a potential neuroprotective strategy following cauda equina injuries. |
| | |
Authors:
|
Marcus Ohlsson; Leif A Havton |
Related Documents
:
|
17622965 - Cyclooxygenase-2 activity following traumatic brain injury in the developing rat. 6658285 - Examination of neutrophil function in a rat model of decreased host resistance followin... 23727175 - Pair housing differentially affects motivation to self-administer cocaine in male and f... 11450005 - L-histidine but not d-histidine attenuates brain edema following cryogenic injury in rats. 10451535 - The effect of adrenaline and walker-256 tumour-induced cachexia upon kupffer cell metab... 22560975 - Effect of chronic exposure to acetaminophen and lincomycin on japanese medaka (oryzias ... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2005-11-11 |
Journal Detail:
|
Title: Neuroscience letters Volume: 394 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2006 Feb |
Date Detail:
|
Created Date: 2006-01-30 Completed Date: 2006-03-30 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
|
Languages: eng Pagination: 179-83 Citation Subset: IM |
Affiliation:
|
Department of Neurology and Brain Research Institute, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095-1769, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Proteins / metabolism, physiology Choline O-Acetyltransferase / metabolism Clusterin / metabolism Complement Activation / physiology* Female Glial Fibrillary Acidic Protein / metabolism Immunohistochemistry Microscopy, Fluorescence Motor Neurons / metabolism, pathology Radiculopathy / metabolism, pathology, physiopathology* Rats Rats, Sprague-Dawley Spinal Cord / pathology Spinal Nerve Roots / pathology |
| Grant Support | |
ID/Acronym/Agency:
|
NS042719/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Blood Proteins; 0/Clusterin; 0/Glial Fibrillary Acidic Protein; EC 2.3.1.6/Choline O-Acetyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Characteristics of captive Japanese black bears (Ursus thibetanus japonicus) semen collected by elec...
Next Document: Dorsal raphe nucleus and locus coeruleus neural networks and the elaboration of the sweet-substance-...