Document Detail


Complement C5a-mediated myocardial ischemia and neutrophil sequestration: two independent phenomena.
MedLine Citation:
PMID:  8447449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The intracoronary infusion of complement C5a causes a decrease in coronary blood flow and contractile dysfunction mediated by thromboxane (TxA2) and leukotrienes. Although these effects are accompanied by polymorphonuclear leukocyte (PMN) sequestration, the role of PMNs and the source of these eicosanoids remain unknown. To assess the contribution of PMNs to the C5a-induced myocardial ischemic response, the left anterior descending (LAD) coronary artery of pigs (n = 13) was cannulated and pump perfused at constant pressure with either normal arterial blood or neutropenic arterial blood (PMN count 0.02 x 10(3) cells/microliters) obtained from animals treated with cyclophosphamide (50 mg/kg iv, given 4 days before). The coronary vein draining the LAD region was cannulated for measurement of leukocyte count and TxB2 levels. Two groups of animals were studied: group 1 (n = 7) neutropenic animals were instrumented and normal animals served as blood donors and group 2 (n = 6) normal animals were instrumented and neutropenic animals served as blood donors. The myocardial response to intracoronary C5a (500 ng) was determined in each animal during coronary perfusion with normal arterial blood and also with neutropenic arterial blood. During perfusion with normal arterial blood, C5a decreased coronary flow to 52.3% and contractile function to 58.8% of preinfusion values. This was accompanied by a transient myocardial accumulation of PMNs (arterial-coronary venous gradient of 5.4 x 10(3) cells/microliters) and increased TxB2 levels in coronary venous blood (from 0.31 to 17.5 ng/ml).(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
U Del Balzo; R L Engler; B R Ito
Related Documents :
6493359 - Different responses of the isolated canine coronary artery superfused with blood or kre...
8688889 - The effect of coronary angioplasty on superoxide anion generation and lipid peroxidatio...
3488139 - Von willebrand's disease prevents occlusive thrombosis in stenosed and injured porcine ...
985409 - Blood-perfused working isolated rat heart.
19699859 - Systematic review of studies of the effect of hyperoxia on coronary blood flow.
17188799 - Vasodilation of epicardial coronary artery can be measured with transthoracic echocardi...
22067519 - Body plan in tetrapods, is it patterned by a hyperbolic tissue flow?
1694619 - Use of permanent magnetic field in reconstructive surgery of the main arteries (experim...
16586489 - Dynamic study of intramembranous particles in human fresh erythrocytes using an "in vit...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  264     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-04-06     Completed Date:  1993-04-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H336-44     Citation Subset:  IM    
Affiliation:
Department of Veterans Affairs Medical Center, Research Service, San Diego, La Jolla, California.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blood Cell Count
Complement C5a / physiology*
Coronary Circulation
Female
Heart / physiopathology
Hemodynamics
Leukocyte Count
Male
Myocardial Ischemia / blood,  etiology*,  physiopathology
Neutrophils / physiology*
Swine
Thromboxane B2 / biosynthesis
Grant Support
ID/Acronym/Agency:
HL-07089-16/HL/NHLBI NIH HHS; HL-17682-16/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
54397-85-2/Thromboxane B2; 80295-54-1/Complement C5a

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Role of PGI2 and epoxyeicosatrienoic acids in relaxation of bovine coronary arteries to arachidonic ...
Next Document:  Effect of captopril on sympathetic preganglionic efferent activity in cats.