Document Detail

Compiled report on clinical efficacy and safety of nifedipine retard 10/20/nifedipine CD 30, as a first-line/add-on therapy in patients of hypertension: ENHANS trial.
MedLine Citation:
PMID:  19585825     Owner:  NLM     Status:  MEDLINE    
The effectiveness of long acting nifedipine (Nicardia retard 10/20/30 CD) was evaluated on Indian patients in multiple centres. This was an open, prospective, clinical multicentric trial. Nearly 1632 patients satisfying the inclusion criteria were selected and given long acting nifedipine and assessed regularly for a period of one month. The reduction in the arterial blood pressure was significant from the 3rd day onwards and the target systolic and diastolic blood pressures were reached by the 14th day and the 7th day respectively, without notable changes in other parameters. At the final visit 18.6% and 16.1% reduction from the baseline was witnessed in the systolic and diastolic blood pressures respectively; 67.3% and 76% of individual patients had achieved target systolic and diastolic pressures respectively at end of one month. The heart rate was also found to be significantly reduced in the course of the trial (2.1% from the baseline). No other physical and investigational parameters were affected. Moreover 56.3% and 55.8% patients and physicians respectively rated the treatment as "very good" or "excellent" at the end of the study period. Thus, from this trial it is clear that long acting nifedipine is very efficacious as a first-line drug in the armamentarium against hypertension, while controlling other modifiable risk factors for cardiovascular disease.
Mayurika Pise; Krishna Prasad Korukonda; P P Walwaikar
Related Documents :
2255005 - Effects of nifedipine on diastolic function in hypertensive patients--an echocardiograp...
9886905 - Study population and treatment titration in the international nifedipine gits study: in...
17169845 - Modulation of peptidyl arginine deiminase 2 and implication for neurodegeneration.
2758105 - Pharmacokinetic interaction between diltiazem and amiodarone in the dog.
9280205 - Psychophysiological reactivity of salt-sensitive normotensive subjects.
18551005 - Blood pressure in late adolescence and early incidence of coronary heart disease and st...
Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  Journal of the Indian Medical Association     Volume:  107     ISSN:  0019-5847     ISO Abbreviation:  J Indian Med Assoc     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-07-09     Completed Date:  2009-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505608     Medline TA:  J Indian Med Assoc     Country:  India    
Other Details:
Languages:  eng     Pagination:  114-6     Citation Subset:  IM    
Medical Department, JB Chemicals and Pharmaceuticals Limited, Mumbai 400030.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Cohort Studies
Drug Therapy, Combination
Hypertension / drug therapy*
Middle Aged
Nifedipine / therapeutic use*
Treatment Outcome
Vasodilator Agents / therapeutic use*
Young Adult
Reg. No./Substance:
0/Vasodilator Agents; 21829-25-4/Nifedipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A postmarketing surveillance study of dexrabeprazole in the treatment of acid peptic disorders.
Next Document:  Medical emergencies in dental practice: 2. Management of specific medical emergencies.