| Competitive solubilization of cholesterol and six species of sterol/stanol in bile salt micelles. | |
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MedLine Citation:
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PMID: 20346931 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Slight differences in the molecular structures of a category of sterol/stanol species affect the solubility of cholesterol in a bile salt solution. We systematically studied the preferential solubilization of cholesterol and sterol/stanol in sodium taurodeoxycholate solutions using relatively minor plant species of sterol/stanol (brassicasterol and stigmasterol) and a non-plant sterol (cholestanol). As relatively major sterol/stanol species (beta-sitosterol, beta-sitostanol, and campesterol) have already been examined using nearly identical procedures to that used in our system, we were able to sufficiently discuss the cholesterol-lowering effects resulting from the molecular structures of six sterol/stanol species. The results of competitive solubilization revealed that cholestanol has the largest cholesterol-lowering effect, decreasing cholesterol solubility to 33% of that in a single solubilizate system. The molecular structure of cholestanol is also most similar to that of cholesterol. In contrast, brassicasterol and stigmasterol have little ability to decrease cholesterol solubility in a mixed binary system. Both have an unsaturated double bond at the side chain of the steroid ring. By applying thermodynamic analyses to these results, we found that the Gibbs energy changes (DeltaG degrees ) of solubilization for sterol/stanol species with cholesterol-lowering effects show larger negative values than that for cholesterol. |
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Authors:
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Keisuke Matsuoka; Eriko Kajimoto; Maho Horiuchi; Chikako Honda; Kazutoyo Endo |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-25 |
Journal Detail:
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Title: Chemistry and physics of lipids Volume: 163 ISSN: 1873-2941 ISO Abbreviation: Chem. Phys. Lipids Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-26 Completed Date: 2010-07-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0067206 Medline TA: Chem Phys Lipids Country: Ireland |
Other Details:
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Languages: eng Pagination: 397-402 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Physical Chemistry, Showa Pharmaceutical University, Higashi-Tamagawagakuen 3-3165, Machida, Tokyo, Japan. matsuoka@ac.shoyaku.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bile Acids and Salts
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chemistry* Cholesterol / chemistry* Micelles Solubility Sterols / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/Micelles; 0/Sterols; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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