Document Detail


Competitive properties of lactate dehydrogenase mutants of the oral bacterium Streptococcus mutans in the rat.
MedLine Citation:
PMID:  6956265     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prior establishment of a lactate dehydrogenase (LDH)-deficient mutant of Streptococcus mutans in the mouths of rats caused a 10-10,000-fold increase in the minimal infectious dose for persistent colonization by wild-type strains of this organism. The finding that LDH-deficient mutants can render their host relatively resistant to infection by decay-causing strains of Strep. mutans while being much less pathogenic themselves, lends support to their prospective usefulness as effector strains in the replacement therapy of dental caries.
Authors:
K P Johnson; J D Hillman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of oral biology     Volume:  27     ISSN:  0003-9969     ISO Abbreviation:  Arch. Oral Biol.     Publication Date:  1982  
Date Detail:
Created Date:  1982-10-29     Completed Date:  1982-10-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0116711     Medline TA:  Arch Oral Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  513-6     Citation Subset:  D; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Dental Caries / therapy
L-Lactate Dehydrogenase / deficiency*
Mouth / microbiology*
Mutation
Rats
Rats, Inbred Strains
Streptococcus mutans / enzymology*
Grant Support
ID/Acronym/Agency:
D04529//PHS HHS
Chemical
Reg. No./Substance:
EC 1.1.1.27/L-Lactate Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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