Document Detail


Competition in the development of nerve connections: a review of models.
MedLine Citation:
PMID:  11254084     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The establishment and refinement of neural circuits involve both the formation of new connections and the elimination of already existing connections. Elimination of connections occurs, for example, in the development of mononeural innervation of muscle fibres and in the formation of ocular dominance columns in the visual cortex. The process that leads to the elimination of connections is often referred to as axonal or synaptic competition. Although the notion of competition is commonly used, the process is not well understood-with respect to, for example, the type of competition, what axons and synapses are competing for, and the role of electrical activity. This article reviews the types of competition that have been distinguished and the models of competition that have been proposed. Models of both the neuromuscular system and the visual system are described. For each of these models, the assumptions on which it is based, its mathematical structure, and the extent to which it is supported by the experimental data are evaluated. Special attention is given to the different modelling approaches and the role of electrical activity in competition.
Authors:
A van Ooyen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Network (Bristol, England)     Volume:  12     ISSN:  0954-898X     ISO Abbreviation:  Network     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-19     Completed Date:  2001-06-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9431867     Medline TA:  Network     Country:  England    
Other Details:
Languages:  eng     Pagination:  R1-47     Citation Subset:  IM    
Affiliation:
Netherlands Institute for Brain Research, Amsterdam. A.van.Ooyen@nih.knaw.nl
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Models, Neurological*
Morphogenesis
Motor Neurons / physiology,  ultrastructure
Nerve Growth Factors / physiology
Nerve Net / growth & development,  physiology*
Neuromuscular Junction / physiology
Synapses / physiology
Visual Pathways / growth & development,  physiology,  ultrastructure
Chemical
Reg. No./Substance:
0/Nerve Growth Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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