Document Detail


Competition and collaboration: GATA-3, PU.1, and Notch signaling in early T-cell fate determination.
MedLine Citation:
PMID:  18768329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
T-cell precursors remain developmentally plastic for multiple cell generations after entering the thymus, preserving access to developmental alternatives of macrophage, dendritic-cell, and even mast-cell fates. The underlying regulatory basis of this plasticity is that early T-cell differentiation depends on transcription factors which can also promote alternative developmental programs. Interfactor competition, together with environmental signals, keep these diversions under control. Here the pathways leading to several lineage alternatives for early pro-T-cells are reviewed, with close focus on the mechanisms of action of three vital factors, GATA-3, PU.1, and Notch-Delta signals, whose counterbalance appears to be essential for T-cell specification.
Authors:
Ellen V Rothenberg; Deirdre D Scripture-Adams
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2008-09-03
Journal Detail:
Title:  Seminars in immunology     Volume:  20     ISSN:  1044-5323     ISO Abbreviation:  Semin. Immunol.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-09-10     Completed Date:  2009-01-02     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  9009458     Medline TA:  Semin Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  236-46     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation / physiology*
GATA3 Transcription Factor / physiology*
Humans
Proto-Oncogene Proteins / physiology*
Receptors, Notch / physiology*
Signal Transduction / physiology*
T-Lymphocytes / physiology*
Trans-Activators / physiology*
Grant Support
ID/Acronym/Agency:
CA90233/CA/NCI NIH HHS; CA98925/CA/NCI NIH HHS; HL089123/HL/NHLBI NIH HHS; R01 CA090233/CA/NCI NIH HHS; R01 CA090233-07/CA/NCI NIH HHS; R01 CA098925/CA/NCI NIH HHS; R01 CA098925-05/CA/NCI NIH HHS; R33 HL089123/HL/NHLBI NIH HHS; R33 HL089123-02/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/GATA3 Transcription Factor; 0/Proto-Oncogene Proteins; 0/Receptors, Notch; 0/Trans-Activators; 0/proto-oncogene protein Spi-1
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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