Document Detail

Competition and collaboration: GATA-3, PU.1, and Notch signaling in early T-cell fate determination.
MedLine Citation:
PMID:  18768329     Owner:  NLM     Status:  MEDLINE    
T-cell precursors remain developmentally plastic for multiple cell generations after entering the thymus, preserving access to developmental alternatives of macrophage, dendritic-cell, and even mast-cell fates. The underlying regulatory basis of this plasticity is that early T-cell differentiation depends on transcription factors which can also promote alternative developmental programs. Interfactor competition, together with environmental signals, keep these diversions under control. Here the pathways leading to several lineage alternatives for early pro-T-cells are reviewed, with close focus on the mechanisms of action of three vital factors, GATA-3, PU.1, and Notch-Delta signals, whose counterbalance appears to be essential for T-cell specification.
Ellen V Rothenberg; Deirdre D Scripture-Adams
Related Documents :
16876109 - Separation of two cell signalling molecules from a symbiotic sponge that modify algal c...
21566279 - Effects of different types of helicobacter pylori on the gap junction intercellular com...
7748559 - Tramtrack acts downstream of numb to specify distinct daughter cell fates during asymme...
22772909 - Chemically modified graphene oxides as a hole transport layer in organic solar cells.
19793889 - The glypican dally is required in the niche for the maintenance of germline stem cells ...
10500159 - Quinolone signaling in the cell-to-cell communication system of pseudomonas aeruginosa.
21036729 - Further studies on barretts mucosa in baboons: metaplastic glandular cells produce sial...
24941119 - Aeg-1 promotes anoikis resistance and orientation chemotaxis in hepatocellular carcinom...
2155539 - Stimulation by thyroid hormone of na+-h+ exchange activity in cultured opossum kidney c...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2008-09-03
Journal Detail:
Title:  Seminars in immunology     Volume:  20     ISSN:  1044-5323     ISO Abbreviation:  Semin. Immunol.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-09-10     Completed Date:  2009-01-02     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  9009458     Medline TA:  Semin Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  236-46     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Differentiation / physiology*
GATA3 Transcription Factor / physiology*
Proto-Oncogene Proteins / physiology*
Receptors, Notch / physiology*
Signal Transduction / physiology*
T-Lymphocytes / physiology*
Trans-Activators / physiology*
Grant Support
CA90233/CA/NCI NIH HHS; CA98925/CA/NCI NIH HHS; HL089123/HL/NHLBI NIH HHS; R01 CA090233/CA/NCI NIH HHS; R01 CA090233-07/CA/NCI NIH HHS; R01 CA098925/CA/NCI NIH HHS; R01 CA098925-05/CA/NCI NIH HHS; R33 HL089123/HL/NHLBI NIH HHS; R33 HL089123-02/HL/NHLBI NIH HHS
Reg. No./Substance:
0/GATA3 Transcription Factor; 0/Proto-Oncogene Proteins; 0/Receptors, Notch; 0/Trans-Activators; 0/proto-oncogene protein Spi-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Quality assurance of 3D-CRT: indications and difficulties in their applications.
Next Document:  Occupational spine biomechanics: a journey to the spinal frontier.