Document Detail

Competition between recently potentiated synaptic inputs reveals a winner-take-all phase of synaptic tagging and capture.
MedLine Citation:
PMID:  25092326     Owner:  NLM     Status:  Publisher    
Canonical models suggest that mechanisms of long-term memory consist of a synapse-specific, protein synthesis-independent induction phase (changes in synaptic weights/temporary tagging of such synapses) and, within adjacent dendritic compartments, a protein synthesis-dependent distribution phase that may accompany or immediately precede induction and whose protein products enable consolidation through synaptic capture. We now report that this distribution phase is competitive in a "winner-take-all" fashion when synapses potentiated at induction compete with each other for plasticity-related proteins. This finding highlights the importance of synaptic competition in creating stable long-lasting memory in neural networks without disruption.
Sreedharan Sajikumar; Richard G M Morris; Martin Korte
Related Documents :
12490386 - Mapping interaction sites of the a20r protein component of the vaccinia virus dna repli...
9371806 - A network of interacting transcriptional regulators involved in drosophila neural fate ...
17308336 - Light chain 1 of microtubule-associated protein 1b can negatively regulate the action o...
10637316 - A compilation of cellular transcription factor interactions with the hiv-1 ltr promoter.
8349826 - 39-kd protein inhibits tissue-type plasminogen activator clearance in vivo.
6299946 - Structure and biological properties of solubilized envelope proteins of bordetella pert...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-4
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  -     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Different tradeoffs result from alternate genetic adaptations to a common environment.
Next Document:  Structural basis for the recognition-evasion arms race between Tomato mosaic virus and the resistanc...