Document Detail

Competition among gene regulatory networks imposes order within the eye-antennal disc of Drosophila.
MedLine Citation:
PMID:  23222441     Owner:  NLM     Status:  MEDLINE    
The eye-antennal disc of Drosophila gives rise to numerous adult tissues, including the compound eyes, ocelli, antennae, maxillary palps and surrounding head capsule. The fate of each tissue is governed by the activity of unique gene regulatory networks (GRNs). The fate of the eye, for example, is controlled by a set of fourteen interlocking genes called the retinal determination (RD) network. Mutations within network members lead to replacement of the eyes with head capsule. Several studies have suggested that in these instances all retinal progenitor and precursor cells are eliminated via apoptosis and as a result the surrounding head capsule proliferates to compensate for retinal tissue loss. This model implies that the sole responsibility of the RD network is to promote the fate of the eye. We have re-analyzed eyes absent mutant discs and propose an alternative model. Our data suggests that in addition to promoting an eye fate the RD network simultaneously functions to actively repress GRNs that are responsible for directing antennal and head capsule fates. Compromising the RD network leads to the inappropriate expression of several head capsule selector genes such as cut, Lim1 and wingless. Instead of undergoing apoptosis, a population of mutant retinal progenitors and precursor cells adopt a head capsule fate. This transformation is accompanied by an adjustment of cell proliferation rates such that just enough head capsule is generated to produce an intact adult head. We propose that GRNs simultaneously promote primary fates, inhibit alternative fates and establish cell proliferation states.
Bonnie M Weasner; Justin P Kumar
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  140     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-10     Completed Date:  2013-01-30     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  205-15     Citation Subset:  IM    
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MeSH Terms
Arthropod Antennae / cytology*,  embryology
Cell Survival / genetics
Drosophila Proteins / genetics
Drosophila melanogaster / cytology,  embryology,  genetics*
Eye / cytology*,  embryology
Eye Proteins / genetics
Feedback, Physiological / physiology
Gene Regulatory Networks / genetics*
Microscopy, Confocal
Stem Cells / cytology,  physiology
Grant Support
Reg. No./Substance:
0/Drosophila Proteins; 0/Eye Proteins; 0/eyes absent protein, Drosophila

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