Document Detail

Competing clocks: Metabolic status moderates signals from the master circadian pacemaker.
MedLine Citation:
PMID:  21693133     Owner:  NLM     Status:  Publisher    
Food anticipation and its behavioural manifestation, food anticipatory activity (FAA), require entrainment of a suprachiasmatic nucleus (SCN) independent circadian mechanism, a food entrainable oscillator (FEO), with an unknown neural substrate. While the FEO entrains to fasting/feeding related cues and drives FAA independently of the pacemaker in the SCN, it must disengage the suppressing signals of the SCN for the behavioural and physiological manifestations of meal anticipation to occur outside of the typical period of arousal. This review provides a brief overview of mammalian circadian biology before summarizing experimental data demonstrating several mechanisms by which this may occur, including: reducing activation of SCN cells receiving retinal input, transient disorganization of SCN outputs, and reduced sensitivity to SCN signals in hypothalamic sites responsible for integrating homeostatic and circadian information. Further investigation of these mechanisms will be key to elucidating pharmacological or behavioural interventions that suppress the negative psychological and health effects of light-driven circadian rhythms in humans, specifically those with work schedules that do not conform to the solar day.
I D Blum; E Waddington Lamont; A Abizaid
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-12
Journal Detail:
Title:  Neuroscience and biobehavioral reviews     Volume:  -     ISSN:  1873-7528     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806090     Medline TA:  Neurosci Biobehav Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Ltd.
Department of Neuroscience, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6.
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