| Competence and competition: the challenge of becoming a long-lived plasma cell. | |
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MedLine Citation:
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PMID: 16977339 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasma cells provide humoral immunity. They have traditionally been viewed mainly as short-lived end-stage products of B-cell differentiation that deserve little interest. This view is changing, however, because we now know that plasma cells can survive for long periods in the appropriate survival niches and that they are an independent cellular component of immunological memory. Studies of the biology of plasma cells reveal a mechanism of intriguing simplicity and elegance that focuses memory provided by plasma cells on recently encountered pathogens while minimizing the 'fading' of memory for pathogens encountered in the distant past. This mechanism is based on competition for survival niches between newly generated plasmablasts and older plasma cells. |
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Authors:
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Andreas Radbruch; Gwendolin Muehlinghaus; Elke O Luger; Ayako Inamine; Kenneth G C Smith; Thomas Dörner; Falk Hiepe |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2006-09-15 |
Journal Detail:
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Title: Nature reviews. Immunology Volume: 6 ISSN: 1474-1733 ISO Abbreviation: Nat. Rev. Immunol. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-09-25 Completed Date: 2006-11-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101124169 Medline TA: Nat Rev Immunol Country: England |
Other Details:
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Languages: eng Pagination: 741-50 Citation Subset: IM |
Affiliation:
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Deutsches Rheuma-Forschungszentrum Berlin, Charitéplatz 1, D-10117 Berlin, Germany. radbruch@drfz.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation / immunology* Humans Immunologic Memory* Plasma Cells / cytology*, immunology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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