Document Detail


Competence and competition: the challenge of becoming a long-lived plasma cell.
MedLine Citation:
PMID:  16977339     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasma cells provide humoral immunity. They have traditionally been viewed mainly as short-lived end-stage products of B-cell differentiation that deserve little interest. This view is changing, however, because we now know that plasma cells can survive for long periods in the appropriate survival niches and that they are an independent cellular component of immunological memory. Studies of the biology of plasma cells reveal a mechanism of intriguing simplicity and elegance that focuses memory provided by plasma cells on recently encountered pathogens while minimizing the 'fading' of memory for pathogens encountered in the distant past. This mechanism is based on competition for survival niches between newly generated plasmablasts and older plasma cells.
Authors:
Andreas Radbruch; Gwendolin Muehlinghaus; Elke O Luger; Ayako Inamine; Kenneth G C Smith; Thomas Dörner; Falk Hiepe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2006-09-15
Journal Detail:
Title:  Nature reviews. Immunology     Volume:  6     ISSN:  1474-1733     ISO Abbreviation:  Nat. Rev. Immunol.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-25     Completed Date:  2006-11-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101124169     Medline TA:  Nat Rev Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  741-50     Citation Subset:  IM    
Affiliation:
Deutsches Rheuma-Forschungszentrum Berlin, Charitéplatz 1, D-10117 Berlin, Germany. radbruch@drfz.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation / immunology*
Humans
Immunologic Memory*
Plasma Cells / cytology*,  immunology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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