Document Detail

Compensatory vasodilatation during hypoxic exercise: mechanisms responsible for matching oxygen supply to demand.
MedLine Citation:
PMID:  22988134     Owner:  NLM     Status:  MEDLINE    
Hypoxia can have profound influences on the circulation. In humans, acute exposure to moderate hypoxia has been demonstrated to result in vasodilatation in the coronary, cerebral, splanchnic and skeletal muscle vascular beds. The combination of submaximal exercise and hypoxia produces a 'compensatory' vasodilatation and augmented blood flow in contracting skeletal muscles relative to the same level of exercise under normoxic conditions. This augmented vasodilatation exceeds that predicted by a simple sum of the individual dilator responses to hypoxia alone and normoxic exercise. Additionally, this enhanced hypoxic exercise hyperaemia is proportional to the hypoxia-induced fall in arterial oxygen (O(2)) content, thus preserving muscle O(2) delivery and ensuring it is matched to demand. Several vasodilator pathways have been proposed and examined as likely regulators of skeletal muscle blood flow in response to changes in arterial O(2) content. The purpose of this review is to put into context the present evidence regarding mechanisms responsible for the compensatory vasodilatation observed during hypoxic exercise in humans. Along these lines, this review will highlight the interactions between various local metabolic and endothelial derived substances that influence vascular tone during hypoxic exercise.
Darren P Casey; Michael J Joyner
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-09-17
Journal Detail:
Title:  The Journal of physiology     Volume:  590     ISSN:  1469-7793     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-17     Completed Date:  2013-06-13     Revised Date:  2013-12-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  6321-6     Citation Subset:  IM    
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MeSH Terms
Adaptation, Physiological
Anoxia / blood,  physiopathology*
Hyperemia / blood,  physiopathology
Muscle Contraction*
Muscle, Skeletal / blood supply*,  metabolism
Oxygen / blood*
Oxygen Consumption*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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