Document Detail


Compensatory increases in milk secretion in response to unilateral inhibition by colchicine during lactation in the goat.
MedLine Citation:
PMID:  6864564     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Milk secretion in one mammary gland of goats was temporarily inhibited by intramammary treatment with colchicine at weeks 6, 12, 18, 24 and 30 of lactation. The magnitude of the inhibition was similar at all stages when compared with milk yield before the experiment. 2. The untreated gland partially compensated for the decreased rate of milk secretion by significantly increasing its own rate of secretion. There was no significant effect of stage of lactation on this response. 3. The rapidity of the compensatory response suggests that existing secretory cells increased their rate of secretion, and therefore that the mammary secretory cells are not secreting at their intrinsic maximum at any stage of lactation. 4. In later stages of lactation (weeks 18, 24 and 30) the increases in the untreated gland were more pronounced in afternoon milkings (8 h milking interval) than in morning milkings (16 h interval. At week 30 only, the rate of secretion before treatment was similarly lower in the 16 h period. It is proposed that an additional limitation is imposed on secretion during the relatively long period of milk accumulation as lactation advances and declines. 5. The results are discussed in relation to rate-limitations on milk secretion with respect to substrate supply and possible systemically active mammary factors.
Authors:
A J Henderson; M Peaker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of physiology     Volume:  334     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-08-11     Completed Date:  1983-08-11     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  433-40     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Colchicine / pharmacology*
Female
Goats / physiology*
Lactation / drug effects*
Mammary Glands, Animal / drug effects
Milk / secretion*
Pregnancy
Secretory Rate / drug effects
Time Factors
Chemical
Reg. No./Substance:
64-86-8/Colchicine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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