Document Detail


Compensatory gastroprotective role of glucocorticoid hormones during inhibition of prostaglandin and nitric oxide production and desensitization of capsaicin-sensitive sensory neurons.
MedLine Citation:
PMID:  17701016     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glucocorticoid hormones produced in response to various ulcerogenic stimuli contribute to the maintenance of the gastric mucosal integrity. The role of glucocorticoids in gastroprotection becomes especially important where there is deficiency of prostaglandins (PGs) or nitric oxide (NO) or desensitization of capsaicin-sensitive sensory neurons (CSN). It has been found that neither inhibition of PG or NO production nor desensitization of CSN by itself provokes damage in the gastric mucosa of rats with normal corticosterone levels. However, each of these treatments results in mucosal damage in adrenalectomized rats; this effect being prevented by corticosterone replacement. Indomethacin-induced gastric erosions are potentiated to similar degrees by adrenalectomy, inhibition of NO production or desensitization of CSN. The potentiation caused by inhibition of NO production or CSN desensitization is further enhanced by concomitant glucocorticoid deficiency. These results suggest a pivotal compensatory role of glucocorticoids in the maintenance of the gastric mucosal integrity under the adverse conditions where the gastroprotective mechanisms provided by PGs, NO and capsaicin-sensitive sensory neurons are impaired.
Authors:
L Filaretova; P Bobryshev; T Bagaeva; T Podvigina; K Takeuchi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Inflammopharmacology     Volume:  15     ISSN:  0925-4692     ISO Abbreviation:  Inflammopharmacology     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-16     Completed Date:  2007-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112626     Medline TA:  Inflammopharmacology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  146-53     Citation Subset:  IM    
Affiliation:
Laboratory of Experimental Endocrinology, Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg 199034, Russia. filaretova@pavlov.infran.ru
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MeSH Terms
Descriptor/Qualifier:
Adrenalectomy
Animals
Capsaicin / administration & dosage,  pharmacology*
Corticosterone / blood,  pharmacology
Gastric Mucosa / drug effects,  innervation,  metabolism*
Glucocorticoids / pharmacology,  physiology*
Indomethacin
Neurons, Afferent / drug effects,  physiology*
Nitric Oxide / biosynthesis*,  deficiency
Prostaglandins / biosynthesis*,  deficiency
Rats
Stomach Ulcer / chemically induced,  drug therapy,  metabolism
Chemical
Reg. No./Substance:
0/Glucocorticoids; 0/Prostaglandins; 10102-43-9/Nitric Oxide; 404-86-4/Capsaicin; 50-22-6/Corticosterone; 53-86-1/Indomethacin

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