| Compensatory evolution in the human malaria parasite Plasmodium ovale. | |
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MedLine Citation:
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PMID: 15020451 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The fixation of neutral compensatory mutations in a population depends on the effective population size of the species, which can fluctuate dramatically within a few generations, the mutation rate, and the selection intensity associated with the individual mutations. We observe compensatory mutations and intermediate states in populations of the malaria parasite Plasmodium ovale. The appearance of compensatory mutations and intermediate states in P. ovale raises interesting questions about population structure that could have considerable impact on the control of the associated disease. |
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Authors:
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Thomas F McCutchan; Dharmendar Rathore; Jun Li |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Genetics Volume: 166 ISSN: 0016-6731 ISO Abbreviation: Genetics Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2004-03-15 Completed Date: 2004-10-26 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0374636 Medline TA: Genetics Country: United States |
Other Details:
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Languages: eng Pagination: 637-40 Citation Subset: IM |
Affiliation:
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Growth and Development Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0425, USA. tmccutchan@niaid.nih.gov |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/AF145337; AJ001527; AJ250701; AY278221; AY278222; AY278223; AY278224; L48986; L48987; U78739; U78740; X99790 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Sequence Evolution, Molecular* Humans Malaria / parasitology Models, Genetic Molecular Sequence Data Mutation Nucleic Acid Conformation Phylogeny Plasmodium ovale / genetics*, pathogenicity RNA, Protozoan / chemistry, genetics RNA, Ribosomal / chemistry, genetics |
| Chemical | |
Reg. No./Substance:
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0/RNA, Protozoan; 0/RNA, Ribosomal |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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