Document Detail


Compatibility of palonosetron with cyclophosphamide and with ifosfamide during simulated Y-site administration.
MedLine Citation:
PMID:  16174835     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The physical and chemical compatibility of palonosetron with cyclophosphamide and with ifosfamide during simulated Y-site administration was studied. METHODS: Test samples were prepared in triplicate by mixing 7.5 mL of palonosetron hydrochloride 50 microg (of palonosetron) per milliliter with 7.5 mL of cyclophosphamide 10 mg/mL and with ifosfamide 20 mg/mL. Physical stability was assessed by turbidimetry, particle sizing, and visual inspection. Chemical stability was assessed by stability-indicating high-performance liquid chromatography. Evaluations were performed immediately and one and four hours after mixing. RESULTS: The samples were clear and colorless when viewed in normal fluorescent room light and when viewed with a high-intensity monodirectional light. Turbidity remained unchanged, and particulate content was low and exhibited little change. Palonosetron, cyclophosphamide, and ifosfamide remained chemically stable throughout the four-hour test period. CONCLUSION: Palonosetron hydrochloride was physically compatible with cyclophosphamide or ifosfamide during simulated Y-site administration.
Authors:
Quanyun A Xu; Lawrence A Trissel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists     Volume:  62     ISSN:  1079-2082     ISO Abbreviation:  Am J Health Syst Pharm     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-21     Completed Date:  2005-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9503023     Medline TA:  Am J Health Syst Pharm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1998-2000     Citation Subset:  IM    
Affiliation:
Division of Pharmacy, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
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MeSH Terms
Descriptor/Qualifier:
Antiemetics / chemistry*
Antineoplastic Agents, Alkylating / chemistry*
Chemistry, Pharmaceutical
Chromatography, High Pressure Liquid
Cyclophosphamide / chemistry*
Drug Stability
Glucose
Ifosfamide / chemistry*
Infusions, Intravenous
Isoquinolines / chemistry*
Pharmaceutical Solutions
Quinuclidines / chemistry*
Chemical
Reg. No./Substance:
0/Antiemetics; 0/Antineoplastic Agents, Alkylating; 0/Isoquinolines; 0/Pharmaceutical Solutions; 0/Quinuclidines; 135729-61-2/palonosetron; 3778-73-2/Ifosfamide; 50-18-0/Cyclophosphamide; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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