Document Detail

Compatibility and stability of ternary admixtures of tramadol, haloperidol, and hyoscine N-butyl bromide: retrospective clinical evaluation.
MedLine Citation:
PMID:  20078209     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Combination of drugs for subcutaneous infusion is common practice in palliative medicine, however, there is no information pertaining to the compatibility and stability of tramadol combined in ternary admixtures and no information exists regarding its clinical performance. METHODS: Tramadol hydrochloride, haloperidol lactate, and hyoscine N-butyl bromide have been examined for compatibility and stability when combined in solution under conditions mimicking their potential use via subcutaneous infusion in terminal oncology patients. Concentration ranges were 8.8-33.3 mg/mL, 0.208-0.624 mg/mL, and 3.33-6.67 mg/mL for tramadol hydrochloride, haloperidol lactate, and hyoscine N-butyl bromide. With these, 27 different admixtures were prepared and stored at 25 degrees C using 0.9% saline as diluent. Quantification was performed by high-performance liquid chromatography (HPLC). The clinical performance of the admixture was retrospectively assessed in 28 terminal oncology patients exhibiting Karnofsky's indexes of 10%-20%. RESULTS: All three drugs were very stable (>92%) at 25 degrees C for 15 days. Pain was completely controlled in all patients. Fifty percent of the patients suffered from 3-5 vomiting episodes per day and of these, 75% experienced complete control of the episodes. None of the patients showed local reactions after subcutaneous administration of the admixture. RESULTS: Our results confirm the compatibility and stability of the ternary admixture and its utility in highly vulnerable patients exhibiting moderate symptoms.
Sofia Negro; Alicia Martín; Luz Azuara; Yolanda Sánchez; Emilia Barcia
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of palliative medicine     Volume:  13     ISSN:  1557-7740     ISO Abbreviation:  J Palliat Med     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-24     Completed Date:  2010-05-20     Revised Date:  2010-09-20    
Medline Journal Info:
Nlm Unique ID:  9808462     Medline TA:  J Palliat Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  273-7     Citation Subset:  IM    
Department of Pharmaceutics, School of Pharmacy, University Complutense of Madrid, Spain.
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MeSH Terms
Aged, 80 and over
Butylscopolammonium Bromide / administration & dosage,  adverse effects,  therapeutic use*
Drug Incompatibility
Drug Stability
Drug Therapy, Combination
Haloperidol / administration & dosage,  adverse effects,  therapeutic use*
Middle Aged
Retrospective Studies
Tramadol / administration & dosage,  adverse effects,  therapeutic use*
Reg. No./Substance:
149-64-4/Butylscopolammonium Bromide; 27203-92-5/Tramadol; 52-86-8/Haloperidol
Comment In:
J Palliat Med. 2010 Sep;13(9):1052   [PMID:  20836629 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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