Document Detail


Compassionate use of everolimus in a patient with a neuroendocrine tumor: a case report and discussion of the literature.
MedLine Citation:
PMID:  22329200     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Neuroendocrine tumors (NETs) represent a relatively rare form of neoplasias for which, in advanced unresectable stages, palliative treatment options remain limited largely to the use of somatostatin analogues or chemotherapy. Several newer targeted therapeutic options, alone or in combination with somatostatin analogues, are currently undergoing clinical evaluation for the treatment of NETs. This article reports the compassionate use of everolimus in combination with long-acting octreotide, in a 58-year old Italian female patient with a well-differentiated neuroendocrine gastric tumor who, since October 2004, has failed multiple previous therapies. Starting in October 2008, the patient has received intramuscular octreotide LAR 30 mg every 28 days plus everolimus 10 mg/day. The patient has reported benefits of symptoms (reduction of pain severity), objective response [improvement of liver function (reductions in LDH, ALP and total bilirubin) and chromogranin A], and radiological response (reduction in target lesions on CT). The patient has experienced an improved quality of life, increased life expectancy, and remains on this well-tolerated treatment regimen.
Authors:
Sara Pusceddu; Massimo Milione; Giuseppe Procopio
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Oncology research     Volume:  19     ISSN:  0965-0407     ISO Abbreviation:  Oncol. Res.     Publication Date:  2011  
Date Detail:
Created Date:  2012-02-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9208097     Medline TA:  Oncol Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  403-6     Citation Subset:  IM    
Affiliation:
Fondazione IRCCS Istituto Nazionale dei Tumori of Milan, Milan, Italy.
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