Document Detail

Compartmentalization of signaling by vesicular trafficking: a shared building design for the immune synapse and the primary cilium.
MedLine Citation:
PMID:  23278743     Owner:  NLM     Status:  MEDLINE    
Accumulating evidence underscores the immune synapse (IS) of naive T cells as a site of intense vesicular trafficking. At variance with helper and cytolytic effectors, which use the IS as a secretory platform to deliver cytokines and/or lytic granules to their cellular targets, this process is exploited by naive T cells as a means to regulate the assembly and maintenance of the IS, on which productive signaling and cell activation crucially depend. We have recently identified a role of the intraflagellar transport (IFT) system, which is responsible for the assembly of the primary cilium, in the non-ciliated T-cell, where it controls IS assembly by promoting polarized T-cell receptor recycling. This unexpected finding not only provides new insight into the mechanisms of IS assembly but also strongly supports the notion that the IS and the primary cilium, which are both characterized by a specialized membrane domain highly enriched in receptors and signaling mediators, share architectural similarities and are homologous structures. Here, we review our current understanding of vesicular trafficking in the regulation of the assembly and maintenance of the naive T-cell IS and the primary cilium, with a focus on the IFT system.
Francesca Finetti; Cosima T Baldari
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  251     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-06-28     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  97-112     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.
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MeSH Terms
Cell Compartmentation / immunology*
Cilia / immunology*
Cytokines / immunology
Cytokinesis / immunology
Cytotoxicity, Immunologic
Immunological Synapses / immunology*
Receptors, Antigen, T-Cell / immunology*
Signal Transduction / immunology
T-Lymphocytes / immunology*
Transport Vesicles / immunology*
Grant Support
Reg. No./Substance:
0/Cytokines; 0/Receptors, Antigen, T-Cell

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