Document Detail

Compartmentalization gamma/delta T cells and their putative role in mucosal immunity.
MedLine Citation:
PMID:  15030308     Owner:  NLM     Status:  MEDLINE    
gamma/delta T cells are an enigmatic group of cells and their functions still remain unknown. The epithelial-associated gamma/delta T cells, which are abundant at mucosal surfaces, are ideally situated to contribute to the initial stages of the immune response. Recent evidence suggests that they recognize stress-induced self-antigens which would enable a homogeneous population of gamma/delta T cells to monitor multiple insults to the epithelium. This could explain the observed oligoclonality and homogeneous distribution of cells carrying identical TCR within mucosal surfaces. However, the analysis of the TCR delta repertoire from different mucosal surfaces indicated that gamma/delta T cells are highly compartmentalized. Thus, gamma/delta T cells are not one homogeneous group of cells which recognize the same (stress-induced) self-antigens, but consist of different subsets that are likely to have distinct functions. It is possible that gamma/delta T cells interact with antigens that are specific for that organ or recognize foreign antigens which are limited to that site. In addition it was shown that gamma/delta T cells can have opposite functions and be proinflammatory or promote epithelial healing. This review focuses on the distribution and repertoire of mucosal gamma/delta T cells and discusses what is currently known about the functions of these cells. Furthermore, their potential role in inflammatory bowel disease is examined.
Wolfgang Holtmeier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Critical reviews in immunology     Volume:  23     ISSN:  1040-8401     ISO Abbreviation:  Crit. Rev. Immunol.     Publication Date:  2003  
Date Detail:
Created Date:  2004-03-19     Completed Date:  2004-10-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8914819     Medline TA:  Crit Rev Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  473-88     Citation Subset:  IM    
Medizinische Klinik II, Division of Gastroenterology, Johann Wolfgang Goethe-Universität, 60590 Frankfurt am Main, Germany.
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MeSH Terms
Antigens, CD1 / metabolism
Autoantigens / metabolism
Chemokines / metabolism
Colitis, Ulcerative / immunology
Crohn Disease / immunology
Histocompatibility Antigens Class I / metabolism
Immunity, Mucosal*
Intestinal Mucosa / cytology,  immunology
Lymphocyte Activation
Models, Immunological
Neoplasms / immunology
Receptors, Antigen, T-Cell, gamma-delta / metabolism*
Sus scrofa
T-Lymphocyte Subsets / immunology*
Wound Healing / immunology
Reg. No./Substance:
0/Antigens, CD1; 0/Autoantigens; 0/Chemokines; 0/Histocompatibility Antigens Class I; 0/MHC class I-related chain A; 0/MICB antigen; 0/Receptors, Antigen, T-Cell, gamma-delta

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