Document Detail

Compartmental organization of the peptide network in the human caudate nucleus.
MedLine Citation:
PMID:  7531455     Owner:  NLM     Status:  MEDLINE    
The mammalian striatum may be divided into a striosomal compartment and a surrounding matrix region. We have examined the distribution of leucine enkephalin (LENK) and substance P (SP) immunoreactivity in relation to striosomes defined by calbindin-D (CABD) staining in alternate 70 microns serial sections from the human caudate nucleus. The distribution of LENK immunoreactivity showed a transition from dorsal to ventral striatum: dorsally, LENK-rich patches were present in a lightly stained matrix; mid-ventrally, annular patches of LENK staining with a lighter core were seen. These patches corresponded to striosomal regions defined by CABD-poor zones. In contrast, in the ventral caudate and nucleus accumbens, LENK-poor zones matched CABD-defined striosomes. CABD staining in the matrix was intense in the dorsal caudate, diminishing ventrally. SP-rich zones in dorsal caudate and SP-poor areas in the mid-ventral region overlapped striosomes. In the ventromedial sector, the SP staining pattern was complex and did not consistently correlate with striosomes. Computer-assisted three-dimensional reconstruction of the striosomal system in the human, based on regions of either high LENK or low CABD immunoreactivity, revealed the existence of considerable long-range order. Patches appeared aligned over several millimeters to form long, horizontal structures in the caudate nucleus, with occasional orthogonal interconnecting crossbridges. Our results are in accord with previous work in the human and in other species. These three-dimensional networks are strikingly similar across individuals and may relate to the segregation of and interactions between striatal circuits.
M S Manley; S J Young; P M Groves
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of chemical neuroanatomy     Volume:  7     ISSN:  0891-0618     ISO Abbreviation:  J. Chem. Neuroanat.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1995-03-16     Completed Date:  1995-03-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8902615     Medline TA:  J Chem Neuroanat     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  191-201     Citation Subset:  IM    
Department of Psychiatry, University of California, San Diego 92093-0603.
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MeSH Terms
Calcium-Binding Protein, Vitamin D-Dependent / analysis
Caudate Nucleus / chemistry*,  ultrastructure
Cell Compartmentation / physiology*
Enkephalin, Leucine / analysis
Image Processing, Computer-Assisted
Middle Aged
Nerve Tissue Proteins / analysis
Neuropeptides / analysis*
Substance P / analysis
Reg. No./Substance:
0/Calcium-Binding Protein, Vitamin D-Dependent; 0/Nerve Tissue Proteins; 0/Neuropeptides; 0/calbindin; 33507-63-0/Substance P; 58822-25-6/Enkephalin, Leucine

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