Document Detail

Compartment analysis of vascular effects of neuropeptides and capsaicin in the pig nasal mucosa.
MedLine Citation:
PMID:  1713399     Owner:  NLM     Status:  MEDLINE    
The vascular effects of local infusion of capsaicin, substance P (SP), calcitonin gene-related peptide (CGRP) and vasoactive intestinal polypeptide (VIP) were monitored in an experimental model on the pig nasal mucosa. Arterial, venous and superficial mucosal blood flow (laser-Doppler flowmetry) as well as mucosal volume, reflecting changes in capacitance vessels were studied in parallel. All substances induced concentration dependent increases in the parameters studied with the exception of the decrease in the superficial mucosal flow induced by vasoactive intestinal polypeptide. This latter finding was interpreted as a stealing phenomenon and suggests that vasoactive intestinal polypeptide mainly exerts its vasodilatory effect in the deeper glandular layers of the nasal mucosa. The vasodilatory effect of capsaicin, except the laser-Doppler signal, was markedly reduced by pretreatment with a combination of the ganglionic blocking agent chlorisondamine and atropine implying that capsaicin evokes a central reflex with a final parasympathetic pathway and release of agents like vasoactive intestinal polypeptide. The remaining capsaicin response may depend on a local effect with axon reflexes and the release of sensory neuropeptides with actions on superficial mucosal blood flow.
P Stjärne; J S Lacroix; A Anggård; J M Lundberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  141     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-08-26     Completed Date:  1991-08-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  335-42     Citation Subset:  IM    
Department of Oto-Rhino-Laryngology, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Atropine / pharmacology
Blood Flow Velocity / drug effects
Calcitonin Gene-Related Peptide / pharmacology
Capsaicin / pharmacology*
Chlorisondamine / pharmacology
Nasal Mucosa / blood supply*,  drug effects
Neuropeptides / pharmacology*
Substance P / pharmacology
Vascular Resistance / drug effects
Vasoactive Intestinal Peptide / pharmacology
Reg. No./Substance:
0/Neuropeptides; 33507-63-0/Substance P; 37221-79-7/Vasoactive Intestinal Peptide; 404-86-4/Capsaicin; 51-55-8/Atropine; 7701-62-4/Chlorisondamine; 83652-28-2/Calcitonin Gene-Related Peptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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