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Comparisons of two different doses of fentanyl for procedural analgesia during epidural catheter placement: a double-blind prospective, randomized, placebo-controlled study.
MedLine Citation:
PMID:  20811917     Owner:  NLM     Status:  In-Data-Review    
The purpose of this study was to investigate the effect of fentanyl on analgesic properties and respiratory responses during an epidural procedure. Sixty patients premedicated with oral brotizolam 0.25 mg were allocated to receive procedural analgesia with saline or 25 or 50 μg of fentanyl. Five minutes after administration, an epidural procedure was started. Pain assessments were made immediately after the epidural catheter placement using a visual analog scale. The lowest SpO(2) levels during the procedure were recorded to evaluate respiratory depression, and cardiovascular complications were also recorded. The pain scores were significantly lower in the 25 and 50 μg fentanyl groups than in the placebo group (P < 0.01). There was no difference in pain assessment between the 25 and 50 μg fentanyl groups. The lowest SpO(2) value of the 50 μg fentanyl group was significantly lower than those of the other groups (P < 0.001). Seven of 20 cases in the 50 μg fentanyl group needed oxygen administration because of a decreased SpO(2) value (<94%). No cardiovascular complications were observed in any group during the entire study period. Thus, intravenous fentanyl at a dose of 25 μg provides effective procedural analgesia without the risk of hypoxemia during an epidural procedure in a patient with preanesthetic medication.
Takeshi Yano; Shigeaki Okubo; Hiroaki Naruo; Tatsuma Iwasaki; Isao Tsuneyoshi
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Publication Detail:
Type:  Journal Article     Date:  2010-09-02
Journal Detail:
Title:  Journal of anesthesia     Volume:  24     ISSN:  1438-8359     ISO Abbreviation:  J Anesth     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8905667     Medline TA:  J Anesth     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  966-9     Citation Subset:  IM    
Department of Anesthesiology, School of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan,
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