| Comparisons of the skeletal muscle metabolic abnormalities in the arm and leg muscles of patients with chronic heart failure. | |
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MedLine Citation:
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PMID: 15170095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: It has been suspected for some time that patients with chronic heart failure (CHF) have abnormal muscle metabolism, so in the present study the muscle metabolism of the arm and leg were compared by (31)P magnetic resonance spectroscopy ((31)P-MRS) to examine the relationship to exercise tolerance. METHODS AND RESULTS: The study group comprised 13 patients and 11 normal controls. Calf-plantar and forearm-wrist flexion were performed to evaluate the metabolic capacity assessed as the phosphocreatine breakdown rate (PCr-slope) and muscle pH at a submaximal (70% peak) work rate (submax-pH). Exercise of both the arm and leg resulted in an earlier decrease in PCr and muscle pH in patients with CHF compared with controls. There were significant correlations between peak oxygen uptake (peak V(O2)) and the PCr-slope in both limbs in patients with CHF (forearm: r=0.63, p<0.05; calf: r=0.60, p<0.05), but no correlations in normal controls. There was a close correlation between the ventilatory anaerobic threshold (AT) and the PCr-slope in the calf (r=0.85, p<0.01), but not in the forearm in patients with CHF. Submax-pH in both upper and lower limbs was not significantly correlated to peak V(O2) or AT in either patients with CHF or controls. CONCLUSIONS: Although metabolic abnormalities during exercise are seen in both arms and legs, leg muscle abnormalities, in particular, are closely related to systemic exercise intolerance in patients with CHF. |
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Authors:
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Tatsuya Nagai; Koichi Okita; Kazuya Yonezawa; Yutaka Yamada; Akiko Hanada; Mitsunori Ohtsubo; Noriteru Morita; Takeshi Murakami; Hirotaka Nishijima; Akira Kitabatake |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 68 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-05-31 Completed Date: 2005-02-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 573-9 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arm Case-Control Studies Chronic Disease Energy Metabolism / physiology* Exercise Test Heart Failure / metabolism*, physiopathology Humans Hydrogen-Ion Concentration Leg Magnetic Resonance Imaging Muscle, Skeletal / metabolism* Oxygen Consumption / physiology Phosphocreatine / analysis Phosphorus Isotopes |
| Chemical | |
Reg. No./Substance:
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0/Phosphorus Isotopes; 67-07-2/Phosphocreatine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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