Document Detail

Comparisons of first and second trimester screening for fetal anomalies.
MedLine Citation:
PMID:  9668713     Owner:  NLM     Status:  MEDLINE    
Four thousand fifty unselected pregnant women bearing a total of 4,078 fetuses were examined by transvaginal sonography (TVS) at 14 weeks of gestational age and rescreened via transabdominal sonography (TAS) at 21 weeks. Fifty-four of 88 anomalies were correctly identified at first scan whereas 34 were not; of these, 24 were discovered at second trimester rescreening, and the remaining 10 were observed later in pregnancy or after birth. The sensitivity of TVS screening with respect to final outcome was 61.4% (54 of 88 malformations in total) and 69.2% in comparison to TAS screening results (54 malformations detected among 78 recognized within 21 weeks). The association between fetal malformation and chromosomal aberrations was also investigated: in our study population there were 21 aneuploidies, 14 of which were recognized because of abnormal findings at the 14 weeks' TVS, 5 at the TAS rescreening, and 2 after birth in neonates free of structural abnormalities.
G D'Ottavio; G Mandruzzato; Y J Meir; M A Rustico; L Fischer-Tamaro; G Conoscenti; R Natale
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  847     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-07-30     Completed Date:  1998-07-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  200-9     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Istituto per l'Infanzia Burlo Garofolo, Trieste, Italy.
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MeSH Terms
Chromosome Aberrations
Congenital Abnormalities / genetics,  ultrasonography*
False Negative Reactions
Fetus / abnormalities*
Infant, Newborn
Pregnancy Trimester, First
Pregnancy Trimester, Second
Sensitivity and Specificity
Ultrasonography, Prenatal* / instrumentation,  methods

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