| Comparisons among sensitivities of different tumor cells to focused ultrasound in vitro. | |
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MedLine Citation:
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PMID: 19278708 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study is to test the sensitivities of different tumor cells to ultrasound irradiation at the frequency of 2.2 MHz for 60 s duration, and investigate the potential mechanism underlying different sensitivities. Three murine tumor models with distinct aggressiveness (S180, H-22 and EAC) were exposed to ultrasound to evaluate their sonodynamic efficiencies, and several biological parameters such as cell membrane permeability, lipid peroxidation (LPO), ultra-structure observation, intracellular reactive oxygen species (ROS) and mitochondria membrane potential (MMP) were analyzed after exposures. The results showed that cellular responses of different cells were distinct, of interest to note, the aggressive S180 cells were much more sensitive than others, whereas EAC cells were relatively more resistant to ultrasound irradiation. The direct comparisons among different types of cells indicate that the sono-sensitization seems to depend on the physiological and chemical properties of tumor cells. Perhaps sections of cell membrane became destabilized following the initial radical attack and LPO reaction, which caused S180 cells more susceptible to mechanical stresses during sonolysis. This study provides important implications for cancer therapy. |
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Authors:
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XiaoBing Wang; QuanHong Liu; Pan Wang; ZheZhi Wang; WanYan Tong; Bo Zhu; Yuan Wang; ChenDi Li |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-02-28 |
Journal Detail:
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Title: Ultrasonics Volume: 49 ISSN: 1874-9968 ISO Abbreviation: Ultrasonics Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-18 Completed Date: 2009-06-16 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0050452 Medline TA: Ultrasonics Country: Netherlands |
Other Details:
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Languages: eng Pagination: 558-64 Citation Subset: IM |
Affiliation:
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College of Life Sciences, Shaanxi Normal University, Shaanxi, Xian 710062, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line, Tumor / metabolism* Cell Membrane / metabolism Cell Survival Flow Cytometry Lipid Peroxidation Mice Microscopy, Electron, Scanning Mitochondria / metabolism Neoplasms / therapy Reactive Oxygen Species / metabolism Sensitivity and Specificity Ultrasonic Therapy / methods Ultrasonics* |
| Chemical | |
Reg. No./Substance:
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0/Reactive Oxygen Species |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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