Document Detail


Comparison of the Young-Laplace law and finite element based calculation of ventricular wall stress: implications for postinfarct and surgical ventricular remodeling.
MedLine Citation:
PMID:  21172505     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Both the Young-Laplace law and finite element (FE) based methods have been used to calculate left ventricular wall stress. We tested the hypothesis that the Young-Laplace law is able to reproduce results obtained with the FE method.
METHODS: Magnetic resonance imaging scans with noninvasive tags were used to calculate three-dimensional myocardial strain in 5 sheep 16 weeks after anteroapical myocardial infarction, and in 1 of those sheep 6 weeks after a Dor procedure. Animal-specific FE models were created from the remaining 5 animals using magnetic resonance images obtained at early diastolic filling. The FE-based stress in the fiber, cross-fiber, and circumferential directions was calculated and compared to stress calculated with the assumption that wall thickness is very much less than the radius of curvature (Young-Laplace law), and without that assumption (modified Laplace).
RESULTS: First, circumferential stress calculated with the modified Laplace law is closer to results obtained with the FE method than stress calculated with the Young-Laplace law. However, there are pronounced regional differences, with the largest difference between modified Laplace and FE occurring in the inner and outer layers of the infarct borderzone. Also, stress calculated with the modified Laplace is very different than stress in the fiber and cross-fiber direction calculated with FE. As a consequence, the modified Laplace law is inaccurate when used to calculate the effect of the Dor procedure on regional ventricular stress.
CONCLUSIONS: The FE method is necessary to determine stress in the left ventricle with postinfarct and surgical ventricular remodeling.
Authors:
Zhihong Zhang; Amod Tendulkar; Kay Sun; David A Saloner; Arthur W Wallace; Liang Ge; Julius M Guccione; Mark B Ratcliffe
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  91     ISSN:  1552-6259     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-21     Completed Date:  2011-02-24     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  150-6     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Algorithms*
Animals
Disease Models, Animal
Finite Element Analysis*
Heart Ventricles
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Myocardial Infarction / complications*,  pathology*,  physiopathology
Reproducibility of Results
Sheep
Stress, Mechanical*
Ventricular Remodeling / physiology*
Grant Support
ID/Acronym/Agency:
R01 HL063348/HL/NHLBI NIH HHS; R01 HL063348-11/HL/NHLBI NIH HHS; R01 HL077921/HL/NHLBI NIH HHS; R01 HL077921-04/HL/NHLBI NIH HHS; R01-HL-63348/HL/NHLBI NIH HHS; R01-HL-77921/HL/NHLBI NIH HHS
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