| Comparison of vitamin E and 25-hydroxyvitamin D absorption during childhood cholestasis. | |
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MedLine Citation:
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PMID: 6631597 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To characterize differences in intestinal absorption of fat-soluble vitamins during cholestasis, intestinal absorption of vitamin E was compared with that of 25-hydroxyvitamin D in eight infants and young children with prolonged neonatal cholestasis. Oral tolerance tests were performed using 100 IU/kg/dose dl-alpha-tocopherol and 10 micrograms/kg/dose 25-hydroxyvitamin D. Mean vitamin E absorption was only 1.0% to 1.9% of that of control children, whereas 25-hydroxyvitamin D absorption was 22.5% to 25.1% of that of controls. Although intestinal absorption of both vitamins is impaired during cholestasis, the severity of vitamin E malabsorption far exceeds that of 25-hydroxyvitamin D. |
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Authors:
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R J Sokol; M K Farrell; J E Heubi; R C Tsang; W F Balistreri |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of pediatrics Volume: 103 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1983 Nov |
Date Detail:
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Created Date: 1983-12-17 Completed Date: 1983-12-17 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 712-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Calcifediol
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administration & dosage,
metabolism* Cholestasis / metabolism* Drug Tolerance Female Humans Infant Infant, Newborn Intestinal Absorption* Male Vitamin E / administration & dosage, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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HD 11725/HD/NICHD NIH HHS; HL-07460/HL/NHLBI NIH HHS; RR-00123/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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1406-18-4/Vitamin E; 19356-17-3/Calcifediol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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