Document Detail

Comparison of ventricular emptying with and without a pressure gradient in patients with hypertrophic cardiomyopathy.
MedLine Citation:
PMID:  4038604     Owner:  NLM     Status:  MEDLINE    
Thirty three patients with hypertrophic cardiomyopathy were studied to determine whether the presence of an intraventricular pressure gradient impaired left ventricular emptying. Patients with resting gradients had a higher mean left ventricular ejection fraction (92 (6.4)%) than patients without a resting or inducible pressure gradient (75.5 (9)%). The rate and degree of emptying increased when gradients greater than 85 mm Hg were induced in two patients with insignificant mitral regurgitation. If the induced gradients had been the result of obstruction a decrease in the rate or degree of ventricular emptying would be expected. Higher ejection fractions in patients with intracavitary pressure gradients as well as enhanced rate and degree of left ventricular emptying with induced gradients are inconsistent with outflow obstruction. These findings support the concept that cavity obliteration is responsible for the pressure gradient in these patients with hypertrophic cardiomyopathy.
R J Siegel; J M Criley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British heart journal     Volume:  53     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-04-18     Completed Date:  1985-04-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  283-91     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure
Cardiomyopathy, Hypertrophic / physiopathology*
Heart / physiopathology*
Heart Ventricles / physiopathology
Middle Aged
Stroke Volume

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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