Document Detail

Comparison of vecuronium- and atracurium-induced neuromuscular blockade in postpartum and nonpregnant patients.
MedLine Citation:
PMID:  1670597     Owner:  NLM     Status:  MEDLINE    
The time-course of action of 0.1 mg/kg vecuronium and 0.5 mg/kg atracurium was investigated in nonpregnant and in postpartum patients within 4 days after delivery. The clinical duration of vecuronium, but not that of atracurium, was significantly prolonged in the latter group (P less than 0.001) and averaged 36 +/- 6 and 37 +/- 4 min for atracurium and 32 +/- 6 and 49 +/- 10 min for vecuronium in nonpregnant and in postpartum patients, respectively (mean +/- SD). In additional in vitro experiments in the rat phrenic nerve-hemidiaphragm preparation no difference could be observed in the neuromuscular blocking effects of vecuronium in postpartum and nonpregnant female rats. It is concluded that pregnancy-induced changes in liver blood flow and/or competition for the liver uptake of sexual hormones might interfere with the hepatic clearance of vecuronium in postpartum patients and thereby cause the observed prolongation of neuromuscular blockade.
K S Khuenl-Brady; J Koller; P Mair; F Pühringer; G Mitterschiffthaler
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  72     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-01-18     Completed Date:  1991-01-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  110-3     Citation Subset:  AIM; IM    
Clinic for Anaesthesia, University of Innsbruck, Austria.
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MeSH Terms
Atracurium / pharmacology*
Neuromuscular Junction / drug effects*
Postpartum Period / drug effects*,  physiology
Rats, Inbred Strains
Synaptic Transmission / drug effects*
Time Factors
Vecuronium Bromide / pharmacology*
Reg. No./Substance:
50700-72-6/Vecuronium Bromide; 64228-79-1/Atracurium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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