Document Detail

Comparison of vasorelaxants in human basilar arteries and umbilical arteries.
MedLine Citation:
PMID:  3243328     Owner:  NLM     Status:  MEDLINE    
The vasodilatation produced by adenosine, sodium nitrite, and papaverine was compared on isolated human basilar arteries and umbilical arteries precontracted with 30 mM KCl or submaximal concentrations of serotonin and prostaglandin F2 alpha. The basilar artery was far more sensitive to the vasodilators than the umbilical vessel. Papaverine, for instance, was 133 times more effective (EC50 = 3.9 x 10(-6) M) in basilar arteries precontracted with KCl than it was in the umbilical artery (EC50 = 5.2 x 10(-4) M) and all dilators inhibited by at least 95% basilar arteries precontracted with serotonin or prostaglandin F2 alpha. In contrast, umbilical arteries precontracted with KCl or prostaglandin F2 alpha failed to relax significantly to adenosine and sodium nitrite at concentrations that exceeded 10(-3) M, and contractions elicited by serotonin were inhibited by less than 40%. The results support the concept that physiological mechanisms responsible for dilation in most vessels are deficient in the umbilical artery and that the deficiency may be related to the role this atypical vessel plays in closure of the extracorporeal circulation at birth.
R P White
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European journal of pharmacology     Volume:  155     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1989-06-06     Completed Date:  1989-06-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  109-15     Citation Subset:  IM    
Department of Pharmacology, University of Tennessee Medical Center, Memphis 38163.
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MeSH Terms
Basilar Artery / drug effects
Dinoprost / pharmacology
Muscle Contraction / drug effects
Muscle Relaxation / drug effects
Muscle, Smooth, Vascular / drug effects*
Potassium Chloride / pharmacology
Serotonin / pharmacology
Umbilical Arteries / drug effects
Grant Support
Reg. No./Substance:
50-67-9/Serotonin; 551-11-1/Dinoprost; 7447-40-7/Potassium Chloride

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