Document Detail

Comparison of a vasodilating beta-blocker and a cardioselective beta-blocker in long-term treatment of hypertension: a European multicentre study.
MedLine Citation:
PMID:  2576667     Owner:  NLM     Status:  MEDLINE    
The therapeutic effectiveness and safety of indenolol, a vasodilating beta-blocker with beta 2-agonism, was compared with that of atenolol, a cardioselective beta-blocker, in a 1-year double-blind trial. A total of 143 hypertensive patients (diastolic blood pressure 95-115 mmHg after 1 month of placebo) were randomly allocated to either atenolol, 50 mg/day, or indenolol, 60 mg/day. If the target diastolic blood pressure (less than or equal to 90 mmHg) was not reached after 1 month, the beta-blocker was doubled. If the target was still not reached, a diuretic was added after 2 months and doubled after 4 months. There was a higher overall responsiveness and monotherapy was more effective in the atenolol group, but at the lower dose indenolol was more effective than atenolol; however, no differences between drugs were significant. Although the drop-out rate was higher with indenolol, withdrawals due to side effects were similar in both groups. Indenolol was as effective and safe as atenolol in long-term antihypertensive therapy.
E Ambrosioni; W Birkenhäger; P W De Leeuw; C Dal Palù; J C Demanet; G Groothold; A Libretti; F Mailland; E Malacco; A Poli
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  7     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-05-11     Completed Date:  1990-05-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S266-7     Citation Subset:  IM    
University of Bologna, Italy.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use*
Antihypertensive Agents / therapeutic use*
Atenolol / therapeutic use*
Blood Pressure / drug effects,  physiology
Double-Blind Method
Heart Rate / drug effects,  physiology
Hypertension / drug therapy*,  physiopathology
Indenes / therapeutic use*
Middle Aged
Multicenter Studies as Topic
Propanolamines / therapeutic use*
Vasodilator Agents / therapeutic use*
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Antihypertensive Agents; 0/Indenes; 0/Propanolamines; 0/Vasodilator Agents; 29122-68-7/Atenolol; 60607-68-3/indenolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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