| Comparison of the validity of magnetic resonance imaging and positron emission tomography/computed tomography in the preoperative evaluation of patients with uterine corpus cancer. | |
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MedLine Citation:
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PMID: 18201753 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare positron emission tomography/computed tomography (PET/CT) with magnetic resonance imaging (MRI) in the preoperative detection of primary lesions and lymph node (LN) and distant metastases in patients with uterine corpus cancer. METHODS: The patient cohort consisted of 53 women with uterine corpus cancer who underwent preoperative workup, including both MRI and PET/CT scans, and underwent surgical staging, including pelvic and/or paraaortic LN dissection, between October 2004 and June 2007 at Asan Medical Center, Seoul, Korea. Pathologic data from surgical staging were compared with the preoperative MRI and PET/CT results. For area specific analysis, LNs were divided into paraaortic, right pelvic and left pelvic areas. RESULTS: In detecting primary lesions, MRI and PET/CT showed no differences in sensitivity (91.5% vs. 89.4%), specificity (33.3% vs. 50.5%), accuracy (84.9% vs. 84.9%), positive predictive value (PPV) (91.5% vs. 93.3%) and negative predictive value (NPV) (33.3% vs. 37.5%). With MRI, the sensitivity, specificity, accuracy, PPV and NPV for detecting metastatic LNs on LN area-by-area analysis were 46.2%, 87.9%, 83.9%, 28.6% and 94.0%, respectively; With PET/CT, those were 69.2%, 90.3%, 88.3%, 42.9%, and 96.6%, respectively. PET/CT showed higher sensitivity, but it did not reach statistical significance (p=0.250). There were also no differences in specificity, accuracy, PPV and NPV. In detecting distant metastasis, the sensitivity, specificity, accuracy, PPV and NPV of PET/CT were 100%, 93.8%, 92.5%, 62.5% and 100%, respectively. CONCLUSION: In patients with uterine corpus cancer, PET/CT had moderate sensitivity, specificity and accuracy in detecting primary lesions and LN metastases, indicating that this method cannot replace surgical staging. The primary benefit of PET/CT is its sensitivity in detecting distant metastases. Because of its high NPV in predicting LN metastasis, PET/CT may also have advantages in selected patients who are poor candidates for surgical staging. |
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Authors:
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Jeong-Yeol Park; Eyu Nyong Kim; Dae-Yeon Kim; Dae-Shik Suh; Jong-Hyeok Kim; Yong-Man Kim; Young-Tak Kim; Joo-Hyun Nam |
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Publication Detail:
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Type: Comparative Study; Journal Article; Validation Studies Date: 2008-01-16 |
Journal Detail:
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Title: Gynecologic oncology Volume: 108 ISSN: 1095-6859 ISO Abbreviation: Gynecol. Oncol. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-02-25 Completed Date: 2008-03-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0365304 Medline TA: Gynecol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 486-92 Citation Subset: IM |
Affiliation:
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Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, #388-1 Poongnap-dong, Songpa-Ku, Seoul, 138-736, South Korea. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Carcinoma, Endometrioid / pathology, radionuclide imaging, surgery Cohort Studies Cystadenocarcinoma, Serous / pathology, radionuclide imaging, surgery Female Humans Korea / epidemiology Lymph Nodes / pathology Lymphatic Metastasis Magnetic Resonance Imaging* Medical Records Middle Aged Neoplasm Staging Pelvis / pathology Positron-Emission Tomography* Predictive Value of Tests Reproducibility of Results Retrospective Studies Sensitivity and Specificity Tomography, X-Ray Computed Uterine Neoplasms / pathology*, radionuclide imaging*, surgery |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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