Document Detail

Comparison of the usefulness of brain perfusion SPECT and MIBG myocardial scintigraphy for the diagnosis of dementia with Lewy bodies.
MedLine Citation:
PMID:  18974648     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Supportive features in the diagnostic criteria for dementia with Lewy bodies (DLB) include occipital hypoperfusion and decreased cardiac uptake of (123)I-metaiodobenzylguanidine (MIBG). In this study, we performed both brain perfusion single photon emission computed tomography (SPECT) and MIBG myocardial scintigraphy in the same subjects and evaluated their sensitivity to detect the characteristic features of DLB. METHODS: Twenty-five patients with probable DLB (76.8 +/- 5.1 years old, 10 male) underwent (99m)Tc-ethylcysteinate dimer brain perfusion SPECT and (123)I-MIBG myocardial scintigraphy. The results of SPECT were analyzed using a qualitative analysis program, easy Z score imaging system (eZIS), and an automated quantitative analysis program, 3DSRT. RESULTS: Qualitative analysis using eZIS demonstrated occipital hypoperfusion in 17 subjects (68%). The quantified mean blood perfusion in the occipital segment on the 3DSRT template was 40.7 +/- 5.03 ml/100 g/min (right) and 40.5 +/- 5.38 ml/100 g/min (left), and in 19 DLB patients these values were below the normal limit. Twenty-four of 25 subjects (96%) had decreased cardiac MIBG uptake in the delayed image. CONCLUSION: MIBG myocardial scintigraphy was superior to brain perfusion SPECT in detecting a characteristic feature of DLB. Our results suggest that combining SPECT and MIBG scintigraphy could increase the accuracy of clinical diagnosis of DLB.
Masaru Tateno; Seiju Kobayashi; Tomohiro Shirasaka; Yoshimori Furukawa; Kazuki Fujii; Hidetoshi Morii; Shuichi Yasumura; Kumiko Utsumi; Toshikazu Saito
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-31
Journal Detail:
Title:  Dementia and geriatric cognitive disorders     Volume:  26     ISSN:  1421-9824     ISO Abbreviation:  Dement Geriatr Cogn Disord     Publication Date:  2008  
Date Detail:
Created Date:  2008-11-21     Completed Date:  2009-02-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9705200     Medline TA:  Dement Geriatr Cogn Disord     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  453-7     Citation Subset:  IM    
Copyright Information:
Copyright 2008 S. Karger AG, Basel.
Department of Neuropsychiatry, Sapporo Medical University, Chuo-ku, Sapporo, Japan.
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MeSH Terms
3-Iodobenzylguanidine / diagnostic use
Aged, 80 and over
Alzheimer Disease / diagnosis,  radionuclide imaging
Brain / radionuclide imaging*
Cerebrovascular Circulation / physiology*
Cysteine / analogs & derivatives,  diagnostic use
Diagnosis, Differential
Heart / radionuclide imaging*
Lewy Body Disease / diagnosis*,  radionuclide imaging*
Occipital Lobe / blood supply
Organotechnetium Compounds / diagnostic use
Radiopharmaceuticals / diagnostic use
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:
0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/technetium Tc 99m bicisate; 52-90-4/Cysteine; 77679-27-7/3-Iodobenzylguanidine

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