Document Detail

Comparison of the use of cabergoline and gonadotrophin to treat primary and secondary anoestrus in bitches.
MedLine Citation:
PMID:  22510079     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE:   To determine the efficacy and reliability of cabergoline and pregnant mare's serum gonadotrophin (PMSG) for induction of oestrus in bitches with primary or secondary anoestrus.
PROCEDURES:   We studied 39 healthy bitches of various breeds aged 2-6 years and in primary or secondary anoestrus: 20 bitches were administered 5 µg/kg/day cabergoline orally until day 2 after the onset of pro-oestrus or for a maximum of 42 days, and 19 bitches were administered 20 IU/kg/day PMSG intramuscularly for 5 consecutive days, followed by an additional single injection of 25 IU/kg of human chorionic gonadotrophin on the fifth day.
RESULTS:   The rates of oestrus induction in the primary and secondary anoestrous bitches treated with cabergoline and PMSG were found to be similar. Pregnancy and whelping rates in the cabergoline group were statistically different from the rates in the PMSG group (P < 0.001).
CONCLUSION:   Cabergoline is more effective and reliable for the induction of a fertile oestrus in bitches with primary or secondary anoestrous.
D Nak; Y Nak; G Simsek
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Australian veterinary journal     Volume:  90     ISSN:  1751-0813     ISO Abbreviation:  Aust. Vet. J.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-18     Completed Date:  2012-05-29     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  0370616     Medline TA:  Aust Vet J     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  194-6     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. Australian Veterinary Journal © 2012 Australian Veterinary Association.
Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, University of Uludag, Dogum ve Jinekoloji Ana Bilim Dali, Bursa, Turkey.
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MeSH Terms
Administration, Oral
Anestrus / drug effects*
Dose-Response Relationship, Drug
Ergolines / administration & dosage,  therapeutic use*
Estrus / drug effects,  physiology
Gonadotropins / administration & dosage,  therapeutic use*
Injections, Intramuscular / veterinary
Ovulation Induction / methods,  veterinary*
Pregnancy Rate
Reg. No./Substance:
0/Ergolines; 0/Gonadotropins; LL60K9J05T/cabergoline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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