Document Detail

Comparison of urological irrigating fluids containing glycine and mannitol in volunteers.
MedLine Citation:
PMID:  10477905     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We compared symptoms and indices of fluid distribution after experimental administration of glycine and mannitol solutions, since these irrigating fluids are sometimes absorbed by the patient during genitourinary surgery. METHODS: Glycine 1.5% and mannitol 3%, both with ethanol 1% added, were given by intravenous infusion at a rate of 0.5 ml/kg/min during 30 min to 12 male volunteers. Symptoms, cognitive status, hemodynamics, electrocardiogram during 24 hr, computerized tomography of the brain, bioimpedance, blood chemistry, and breath ethanol concentrations were recorded. RESULTS: Glycine was associated with more symptoms than mannitol (P< 0.006), but the cognitive status, computerized tomography examinations, electrocardiograms, and breath ethanol concentrations did not differ between the solutions. The urinary excretion of fluid and sodium was greater after mannitol (P< 0.04), while only the glycine infusions hydrated the cells (P< 0.05). For both fluids, the intravascular and interstitial volumes were below baseline 3 hr after the experiment started (P< 0.01). CONCLUSIONS: Glycine 1.5% had a higher tendency than mannitol 3% to cause symptoms and to accumulate in the cells.
L Sandfeldt; R G Hahn
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Prostate     Volume:  41     ISSN:  0270-4137     ISO Abbreviation:  Prostate     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-10-19     Completed Date:  1999-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8101368     Medline TA:  Prostate     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  89-98     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Wiley-Liss, Inc.
Department of Urology, Huddinge University Hospital, Huddinge, Sweden.
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MeSH Terms
Diuretics, Osmotic / adverse effects*,  pharmacokinetics
Glycine / adverse effects*,  pharmacokinetics
Irrigation / adverse effects
Mannitol / adverse effects*,  pharmacokinetics
Postoperative Complications
Prostate / surgery
Tissue Distribution
Urologic Surgical Procedures / adverse effects
Water-Electrolyte Balance
Reg. No./Substance:
0/Diuretics, Osmotic; 56-40-6/Glycine; 69-65-8/Mannitol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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