| Comparison of urodynamic effects of phytoestrogens equol, puerarin and genistein with these of estradiol 17beta in ovariectomized rats. | |
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MedLine Citation:
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PMID: 19903517 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Whether urinary incontinence in the postmenopause can be prevented or delayed by estrogens is currently controversially debated. Ovariectomized (ovx) rats have been successfully used as models in the past years but plant derived substances with estrogenic effects in the lower urinary tract have not been studied so far. Therefore we compared the effects of a 3 months lasting oral administration of estradiol 17beta (E2) with those of the phytoestrogens equol, genistein and puerarin. They were ovariectomized, fed with test substance containing food and then anaesthetized and catheterized with a biluminal catheter having one outlet in the bladder and another in the urethra at the level of the urethral sphincter. Urethral and bladder pressure were recorded during a 240s period of retrograde bladder filling (2 x 0.5 ml within 30s with 1 min filling intermission). Bladder and urethra pressures were highest in the E2>puerarin>equol>genistein treated animals. Phytoestrogen and E2 treatment resulted in consistently higher urethral than the bladder pressures during the filling period and in the filled status whereas bladder often exceeded urethral pressures in ovx controls. In summary, we demonstrate significant improvement of urethral closure mechanism under E2 and phytoestrogen administration that can be assumed to be beneficial for prevention or therapy of postmenopausal urge incontinence. |
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Authors:
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Anke Thielemann; Wolfgang Wuttke; Marcus Wuttke; Dana Seidlova-Wuttke |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-10 |
Journal Detail:
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Title: Experimental gerontology Volume: 45 ISSN: 1873-6815 ISO Abbreviation: Exp. Gerontol. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-01 Completed Date: 2010-04-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0047061 Medline TA: Exp Gerontol Country: England |
Other Details:
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Languages: eng Pagination: 129-37 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Endocrinology, University Medical Center G?ttingen, Georg-August-University, Robert-Koch-Strasse 40, G?ttingen, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology Animals Estradiol / pharmacology* Female Genistein / pharmacology* Isoflavones / pharmacology* Ovariectomy Phytoestrogens / pharmacology* Pressure Rats Rats, Sprague-Dawley Urethra / drug effects, physiology Urinary Bladder / drug effects, physiology Urinary Incontinence / drug therapy*, prevention & control Urodynamics / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Isoflavones; 0/Phytoestrogens; 3681-99-0/puerarin; 446-72-0/Genistein; 50-28-2/Estradiol; 531-95-3/equol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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